The β1-adrenergic receptor (β1AR) Arg389Gly polymorphism affects responses to orally
administered β1AR antagonists (β-blockers) in vivo. However, the effect of this …

A gene–drug interaction has been indicated between β1‐adrenoceptor‐selective beta‐
blockers and the A rg389 G ly polymorphism (rs1801253) in the adrenergic beta‐1 receptor …

Objectives Black patients may be less responsive to β-blockers than whites. Genetic variants
in the β 1-adrenergic receptor (β 1-AR) associated with lesser response to β-blockers are …

Background A common polymorphism of the β1‐adrenergic receptor Arg389Gly markedly
affects function in vitro, but little is known about its in vivo significance. Methods and results …

Abstract β‐Blockers' heart rate (HR)‐lowering effect is an important determinant of the
effectiveness for this class of drugs, yet it is variable among β‐blocker–treated patients. To …

Objectives Our objectives were to determine whether the Gly389 polymorphism of the β1‐
adrenergic receptor exhibits reduced responsiveness in vivo and to test the hypothesis that …

Objectives Recently, the Arg389Gly β 1-adrenoceptor (β 1 AR) gene polymorphism has
been detected. The Arg variant exhibited increased responsiveness to agonist-induced …

The β-adrenergic receptors (βAR) play important roles in cardiovascular function and
disease, and both agonists and antagonists are widely used in various settings for treatment …

Abstract In vitro, Arg389Gly β 1-adrenoceptor (AR) polymorphism exhibits decreased β-AR
signalling. In vivo, β 1-AR-mediated cardiac effects of exercise showed no genotype …

There are marked interethnic differences in β 1-adrenoceptor-mediated responsiveness,
with sensitivity decreased in African-Americans and increased in Chinese compared with …