Since conventional and targeted therapies aiming at cancer cells have largely failed to
prolong survival in pancreatic cancer, targeting the infrastructure of the tumor, hence its …

Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in
pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has
received little attention until recent times. Given that treatments focusing on pancreatic …

Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile
molecular behavior and complex tumor microenvironment. It has been recently postulated …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

Pancreatic stellate cells are stromal cells that have multiple physiological functions such as
the production of extracellular matrix, stimulation of amylase secretion, phagocytosis and …

Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Pancreatic cancer is characterized by its late detection, aggressive growth, intense
infiltration into adjacent tissue, early metastasis, resistance to chemo-and radiotherapy and …

The importance of the stromal compartment in the development, proliferation, invasion,
metastasis and resistance of epithelial cancers has increasingly been recognized in recent …

One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an
abundant desmoplastic/stromal reaction. Until recently, this stroma had received little …