Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry

G Simmons, JD Reeves… - Proceedings of the …, 2004 - National Acad Sciences
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly
emerging pathogen with potentially serious consequences for public health. Here we …

Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association

J Sui, W Li, A Murakami, A Tamin… - Proceedings of the …, 2004 - National Acad Sciences
Effective prophylaxis and antiviral therapies are urgently needed in the event of
reemergence of the highly contagious and often fatal severe acute respiratory syndrome …

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

G Simmons, DN Gosalia… - Proceedings of the …, 2005 - National Acad Sciences
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-
CoV), for which there is currently no effective treatment. SARS-CoV mediates receptor …

Structural characterization of the SARS-coronavirus spike S fusion protein core

B Tripet, MW Howard, M Jobling, RK Holmes… - Journal of Biological …, 2004 - ASBMB
The spike (S) glycoprotein of coronaviruses mediates viral entry into host cells. It is a type 1
viral fusion protein that characteristically contains two heptad repeat regions, denoted HR-N …

Identification of two critical amino acid residues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a …

XX Qu, P Hao, XJ Song, SM Jiang, YX Liu… - Journal of Biological …, 2005 - ASBMB
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a recently identified human
coronavirus. The extremely high homology of the viral genomic sequences between the …

Domains and functions of spike protein in Sars-Cov-2 in the context of vaccine design

X Xia - Viruses, 2021 - mdpi.com
The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to
gain entry into a cell to initiate infection. Both Pfizer/BioNTech's BNT162b2 and Moderna's …

Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor

GJ Babcock, DJ Esshaki, WD Thomas Jr… - Journal of …, 2004 - Am Soc Microbiol
ABSTRACT A novel coronavirus, severe acute respiratory syndrome coronavirus (SARS-
CoV), has recently been identified as the causative agent of severe acute respiratory …

The spike protein of SARS-CoV—a target for vaccine and therapeutic development

L Du, Y He, Y Zhou, S Liu, BJ Zheng… - Nature Reviews …, 2009 - nature.com
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused
by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is …

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

A Shulla, T Heald-Sargent, G Subramanya… - Journal of …, 2011 - Am Soc Microbiol
Spike (S) proteins, the defining projections of the enveloped coronaviruses (CoVs), mediate
cell entry by connecting viruses to plasma membrane receptors and by catalyzing …

[HTML][HTML] Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein

S Duquerroy, A Vigouroux, PJM Rottier, FA Rey… - Virology, 2005 - Elsevier
The coronavirus spike glycoprotein is a class I membrane fusion protein with two
characteristic heptad repeat regions (HR1 and HR2) in its ectodomain. Here, we report the X …