J Sui, W Li, A Murakami, A Tamin… - Proceedings of the …, 2004 - National Acad Sciences
Effective prophylaxis and antiviral therapies are urgently needed in the event of reemergence of the highly contagious and often fatal severe acute respiratory syndrome …
G Simmons, DN Gosalia… - Proceedings of the …, 2005 - National Acad Sciences
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS- CoV), for which there is currently no effective treatment. SARS-CoV mediates receptor …
B Tripet, MW Howard, M Jobling, RK Holmes… - Journal of Biological …, 2004 - ASBMB
The spike (S) glycoprotein of coronaviruses mediates viral entry into host cells. It is a type 1 viral fusion protein that characteristically contains two heptad repeat regions, denoted HR-N …
XX Qu, P Hao, XJ Song, SM Jiang, YX Liu… - Journal of Biological …, 2005 - ASBMB
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a recently identified human coronavirus. The extremely high homology of the viral genomic sequences between the …
The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to gain entry into a cell to initiate infection. Both Pfizer/BioNTech's BNT162b2 and Moderna's …
GJ Babcock, DJ Esshaki, WD Thomas Jr… - Journal of …, 2004 - Am Soc Microbiol
ABSTRACT A novel coronavirus, severe acute respiratory syndrome coronavirus (SARS- CoV), has recently been identified as the causative agent of severe acute respiratory …
L Du, Y He, Y Zhou, S Liu, BJ Zheng… - Nature Reviews …, 2009 - nature.com
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is …
A Shulla, T Heald-Sargent, G Subramanya… - Journal of …, 2011 - Am Soc Microbiol
Spike (S) proteins, the defining projections of the enveloped coronaviruses (CoVs), mediate cell entry by connecting viruses to plasma membrane receptors and by catalyzing …
S Duquerroy, A Vigouroux, PJM Rottier, FA Rey… - Virology, 2005 - Elsevier
The coronavirus spike glycoprotein is a class I membrane fusion protein with two characteristic heptad repeat regions (HR1 and HR2) in its ectodomain. Here, we report the X …