To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

Tissue regeneration involves complex processes in the interaction between different cell
types that control the process of neo-vascularization. In bone, osteoblasts and bone marrow …

In vitro vascularization is an upcoming strategy to solve the problem of insufficient blood
supply after implantation. Although recent publications show promising results, these studies …

Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

The neovascularization of three‐dimensional voluminous tissues, such as bone, represents
an important challenge in tissue engineering applications. The formation of a preformed …

In vitro prevascularization of bone grafts with endothelial progenitor cells (EPCs) is a
promising strategy to improveimplant survival. In this study we show bone formation in …

In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered
bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen …

Bone is a highly vascularized tissue, in which vascularization and mineralization are
concurrent processes during skeletal development. Indeed, both components should be …

There have been extensive research efforts to develop new strategies for bone tissue
engineering. These have mainly focused on vascularization during the development and …

Angiogenesis is a key element in early wound healing and is considered important for tissue
regeneration and for directing inflammatory cells to the wound site. The improvement of …