Metallodrugs for the treatment of trypanosomatid diseases: Recent advances and new insights

M Navarro, R Justo, GYS Delgado… - Current Pharmaceutical …, 2021 - ingentaconnect.com
Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

[PDF][PDF] Metal-and metalloid-containing drugs for the treatment of trypanosomatid diseases

G Colotti, A Fiorillo, A Ilari - Front. Biosci, 2018 - article.imrpress.com
The trypanosomatid-induced diseases are considered as neglected, because the countries
where they kill people are not important markets for western big pharmaceutical companies …

Metal complexes as chemotherapeutic agents against tropical diseases: trypanosomiasis, malaria and leishmaniasis

RA Sánchez-Delgado… - Mini reviews in medicinal …, 2004 - ingentaconnect.com
Parasitic diseases represent a major world health problem with very limited therapeutic
options, most of the available treatments being decades old and suffering from limited …

Metal compounds in the development of antiparasitic agents: rational design from basic chemistry to the clinic

D Gambino, L Otero - Met. Ions Life Sci, 2019 - degruyter.com
Metal compounds seem to be a promising approach in the search of new therapeutic
solutions for neglected tropical diseases. In this chapter, efforts in the design of prospective …

Prospective metallo-drugs including bioactive compounds: selection of co-ligands to tune biological activity against neglected tropical diseases

D Gambino, L Otero - Targeted Metallo-Drugs, 2023 - taylorfrancis.com
194Metal complexes have demonstrated to be a promising alternative in the search of new
drugs for the treatment of neglected tropical diseases and, particularly, those caused by …

Organometallic compounds in the discovery of new agents against kinetoplastid-caused diseases

M Ravera, E Moreno-Viguri, R Paucar… - European Journal of …, 2018 - Elsevier
The development of safe and affordable antiparasitic agents effective against neglected
tropical diseases is a big challenge of the drug discovery. The drugs currently employed …

Design of prospective antiparasitic metal-based compounds including selected organometallic cores

D Gambino, L Otero - Inorganica Chimica Acta, 2018 - Elsevier
A group of seventeen communicable and poverty-related diseases are considered
neglected by the World Health Organization due to the restricted development of diagnostic …

Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives

M Navarro, C Gabbiani, L Messori, D Gambino - Drug discovery today, 2010 - Elsevier
Tropical diseases today constitute a major health problem and a big challenge for drug
discovery. Because of the limited arsenal of effective antiparasitic agents and the frequent …

Medicinal organometallic compounds with anti-chagasic activity

MB Camarada, C Echeverria, R Ramirez-Tagle - MedChemComm, 2016 - pubs.rsc.org
Chagas' disease (CD) is one of the most important neglected tropical disorders, being a
major health concern in Latin America. CD is caused by the protozoan parasite …

Facing diseases caused by trypanosomatid parasites: rational design of Pd and Pt complexes with bioactive ligands

D Gambino, L Otero - Frontiers in Chemistry, 2022 - frontiersin.org
Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis
(CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites …