A neuromuscular perspective of sarcopenia pathogenesis: Deciphering the signaling pathways involved

A Moreira-Pais, R Ferreira, PA Oliveira, JA Duarte - Geroscience, 2022 - Springer
The escalation of life expectancy is accompanied by an increase in the prevalence of age-
related conditions, such as sarcopenia. Sarcopenia, a muscle condition defined by low …

Neuromuscular junction aging: a role for biomarkers and exercise

J Pratt, G De Vito, M Narici… - The Journals of …, 2021 - academic.oup.com
Age-related skeletal muscle degradation known as “sarcopenia” exerts considerable strain
on public health systems globally. While the pathogenesis of such atrophy is undoubtedly …

The biological foundations of sarcopenia: established and promising markers

M Casati, AS Costa, D Capitanio, L Ponzoni… - Frontiers in …, 2019 - frontiersin.org
Sarcopenia, the progressive loss of muscle mass and strength, is one of the major health
issues in older adults, given its high prevalence accompanied by huge clinical and …

Muscle weakness and neuromuscular junctions in aging and disease

K Shigemoto, S Kubo, S Mori, S Yamada… - Geriatrics & …, 2010 - Wiley Online Library
A critical issue in today's super‐aging society is the need to reduce the burden of family care
while continuing to make our medical institutions supportive. A rapidly emerging, major …

[HTML][HTML] Mechanisms regulating neuromuscular junction development and function and causes of muscle wasting

LA Tintignac, HR Brenner… - Physiological …, 2015 - journals.physiology.org
The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

Adaptive remodeling of the neuromuscular junction with aging

MR Deschenes, R Flannery, A Hawbaker, L Patek… - Cells, 2022 - mdpi.com
Aging is associated with gradual degeneration, in mass and function, of the neuromuscular
system. This process, referred to as “sarcopenia”, is considered a disease by itself, and it …

Neuromuscular junction transmission failure in aging and sarcopenia: The nexus of the neurological and muscular systems

WD Arnold, BC Clark - Ageing Research Reviews, 2023 - Elsevier
Sarcopenia, or age-related decline in muscle form and function, exerts high personal,
societal, and economic burdens when untreated. Integrity and function of the neuromuscular …

Sarcopenia–The search for emerging biomarkers

A Kalinkovich, G Livshits - Ageing research reviews, 2015 - Elsevier
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the life quality of elder people. In view of increasing life expectancy, sarcopenia …

Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

The neuromuscular junction: aging at the crossroad between nerves and muscle

M Gonzalez-Freire, R de Cabo… - Frontiers in aging …, 2014 - frontiersin.org
Aging is associated with a progressive loss of muscle mass and strength and a decline in
neurophysiological functions. Age-related neuromuscular junction (NMJ) plays a key role in …