The study of rheumatic diseases draws on many genome-scale technologies. Box 1 defines
relevant terms that will be used in this discussion. Genome-wide association studies …

Rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and some other
rheumatic diseases are genetically complex, with evidence of familial clustering, but not of …

Autoimmune diseases develop through the exposure of genetically susceptible hosts to
environmental triggers. Advances in high-throughput genotyping and sequencing …

Background Rheumatic diseases are autoimmune diseases that are characterized by
inflammation and destruction of joints, muscles, blood vessels, and organs. Both genetic and …

Autoimmune diseases are caused by multiple factors. Rheumatoid Arthritis (RA) is one of the
most common human systemic autoimmune diseases with a prevalence of 0.5%–1 …

The rheumatic diseases are a family of chronic systemic illnesses characterized by immune
dysregulation that ultimately lead to inflammation, internal organ injury, and in some cases …

Genetic factors are increasingly recognized to have an important contribution to the
occurrence of both inflammatory and noninflammatory rheumatic disease. Although …

The study of complex genetics in autoimmune diseases has progressed at a tremendous
pace over the last 4 years, as a direct result of the enormous gains made by genome wide …

Background Rheumatoid arthritis (RA) shares genetic variants with other autoimmune
conditions, but existing studies test the association between RA variants with a pre-defined …

Genetics represents one of the most powerful and direct approaches to investigating the
basis of human disease. In recent years, this approach has been greatly advanced by the …