Long interspersed nucleotide element 1 (L1) is a family of non-LTR retrotransposons that
can replicate and reintegrate into the host genome. L1s have considerably influenced …

Endogenous mobile genetic elements can give rise to de novo germline or somatic
mutations that can have dramatic consequences for genome regulation both local and …

Whether somatic mutations contribute functional diversity to brain cells is a long-standing
question. Single-neuron genomics enables direct measurement of somatic mutation rates in …

More than half of human genome is comprised of transposable elements (TEs), most of
which are the retrotransposons (or class I TEs). As the name suggests, retrotransposons …

Summary Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source
of genotypic variation among neurons. As a neurogenic niche, the hippocampus supports …

SVA is a composite repetitive element named after its main components, SINE, VNTR and
Alu. We have identified 2762 SVA elements from the human genome draft sequence …

SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are
associated with disease in humans. SVAs are evolutionarily young and presumably …

Retrotransposons can cause somatic genome variation in the human nervous system, which
is hypothesized to have relevance to brain development and neuropsychiatric disease …

INTRODUCTION The characterization of the full spectrum of genetic variation is critical to
understanding human health and disease. Recent technological advances have made it …

Half the human genome is made of transposable elements (TEs), whose ongoing activity
continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon …