Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction
(VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is …

Methylglyoxal (MG), a reactive metabolite of glucose, has high affinity for arginine and is a
precursor of advanced glycation endproducts (AGEs). We tested the hypothesis that l …

The incidence of cardiovascular disease is predicted to increase as the population ages.
There is accumulating evidence that arginase upregulation is associated with impaired …

The increase of vascular arginase activity during aging causes endothelial dysfunction. This
enzyme competes with the endothelial nitric oxide synthase (eNOS) for L-arginine substrate …

Endothelial dysfunction is a characteristic feature in diabetes that contributes to the
development of vascular disease. Recently, arginase has been implicated in triggering …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Diabetes-induced vascular endothelial dysfunction has been reported to involve
hyperglycemia-induced increases in arginase activity. However, upstream mediators of this …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Atherosclerotic vascular disease is the leading cause of morbidity and mortality in
developed countries. While it is a complex condition resulting from numerous genetic and …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …