Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

IS Patten, S Rana, S Shahul, GC Rowe, C Jang, L Liu… - Nature, 2012 - nature.com
Peripartum cardiomyopathy (PPCM) is an often fatal disease that affects pregnant women
who are near delivery, and it occurs more frequently in women with pre-eclampsia and/or …

Molecular mechanisms of peripartum cardiomyopathy: a vascular/hormonal hypothesis

NA Bello, Z Arany - Trends in cardiovascular medicine, 2015 - Elsevier
Peripartum cardiomyopathy (PPCM) is characterized by the development of systolic heart
failure in the last month of pregnancy or within the first 5 months postpartum. The disease …

Pathophysiology and risk factors of peripartum cardiomyopathy

MF Hoes, Z Arany, J Bauersachs… - Nature Reviews …, 2022 - nature.com
Peripartum cardiomyopathy (PPCM) is a potentially fatal form of idiopathic heart failure with
variable prevalence across different countries and ethnic groups. The cause of PPCM is …

Relaxin-2 and soluble Flt1 levels in peripartum cardiomyopathy: results of the multicenter IPAC study

J Damp, MM Givertz, M Semigran, R Alharethi… - JACC: Heart Failure, 2016 - jacc.org
Objectives: This study explored the association of vascular hormones with myocardial
recovery and clinical outcomes in peripartum cardiomyopathy (PPCM). Background: PPCM …

Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life

F Lu, E Bytautiene, E Tamayo, P Gamble… - American journal of …, 2007 - Elsevier
OBJECTIVE: The purpose of this study was to determine whether fetal programming of adult
blood pressure is altered in a previously characterized mouse model of preeclampsia that …

Pathophysiology and epidemiology of peripartum cardiomyopathy

D Hilfiker-Kleiner, K Sliwa - Nature reviews cardiology, 2014 - nature.com
Cardiovascular diseases are a major cause of complications in pregnancy worldwide, and
the number of patients who develop cardiac problems during pregnancy is increasing …

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

K Kanasaki, K Palmsten, H Sugimoto, S Ahmad… - Nature, 2008 - nature.com
Despite intense investigation, mechanisms that facilitate the emergence of the pre-
eclampsia phenotype in women are still unknown. Placental hypoxia, hypertension …

Bromocriptine for the treatment of peripartum cardiomyopathy: welcome on BOARD

M Arrigo, A Blet, A Mebazaa - European heart journal, 2017 - academic.oup.com
Peripartum cardiomyopathy (PPCM), according to the actual definition proposed by the
Study Group on PPCM of the Heart Failure Association of the European Society of …

Peripartum cardiomyopathy: basic mechanisms and hope for new therapies

M Ricke-Hoch, TJ Pfeffer… - Cardiovascular …, 2020 - academic.oup.com
Peripartum cardiomyopathy (PPCM) is a life-threatening cardiomyopathy characterized by
acute or slow progression of left ventricular (LV) systolic dysfunction (LV ejection fraction of< …

Genetic and phenotypic landscape of peripartum cardiomyopathy

R Goli, J Li, J Brandimarto, LD Levine, V Riis… - Circulation, 2021 - Am Heart Assoc
Background: Peripartum cardiomyopathy (PPCM) occurs in≈ 1: 2000 deliveries in the
United States and worldwide. The genetic underpinnings of PPCM remain poorly defined …