Activated pancreatic stellate cells (PSCs) are the main effector cells in the process of
fibrosis, a major pathological feature in pancreatic diseases that including chronic …

While the morphology and function of cells of the exocrine and endocrine pancreas have
been studied over several centuries, one important cell type in the gland, the pancreatic …

Improved understanding of the role of PSCs in pancreatic pathophysiology has prompted a
focus on translational studies aimed at developing novel approaches to modulate PSC …

Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

Abstract Background Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic
fibrosis, a characteristic feature of pancreatic cancer. Although it is still controversial …

Pancreatic fibrosis is a characteristic feature of chronic pancreatitis and of desmoplastic
reaction associated with pancreatic cancer. For over a decade, there has been accumulating …

Background Pancreatic stellate cells (PSCs) is a highly heterogeneic stroma cell population
in pancreatic cancer tissue. Interaction between PSCs and pancreatic cancer cells has not …

Late diagnosis and ineffective therapeutic options mean that pancreatic ductal
adenocarcinoma (PDA) is one of the most lethal forms of human cancer. The identification of …

There is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal
role in pancreatic fibrosis in chronic pancreatitis and pancreatic cancer. In addition, we have …

Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic
extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over …