Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression
Glutamate is the predominant excitatory amino acid neurotransmitter in the mammalian
central nervous system (CNS). Glutamate transporter EAAT2/GLT-1 is the physiologically …
central nervous system (CNS). Glutamate transporter EAAT2/GLT-1 is the physiologically …
Current approaches to enhance glutamate transporter function and expression
ACK Fontana - Journal of neurochemistry, 2015 - Wiley Online Library
Abstract l‐glutamate is the predominant excitatory neurotransmitter in the CNS and has a
central role in a variety of brain functions. The termination of glutamate neurotransmission by …
central role in a variety of brain functions. The termination of glutamate neurotransmission by …
Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: an in vitro study of maslinic acid
The astrocytic glutamate transporters GLAST/EAAT1 and GLT-1/EAAT2 are crucial for the
removal of glutamate from the synaptic cleft and are essential for maintaining a low …
removal of glutamate from the synaptic cleft and are essential for maintaining a low …
Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes
SG Lee, ZZ Su, L Emdad, P Gupta, D Sarkar… - Journal of Biological …, 2008 - ASBMB
Glutamate is an essential neurotransmitter regulating brain functions. Excitatory amino acid
transporter (EAAT)-2 is one of the major glutamate transporters primarily expressed in …
transporter (EAAT)-2 is one of the major glutamate transporters primarily expressed in …
Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection
Glial glutamate transporter EAAT2 plays a major role in glutamate clearance in synaptic
clefts. Several lines of evidence indicate that strategies designed to increase EAAT2 …
clefts. Several lines of evidence indicate that strategies designed to increase EAAT2 …
Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease
K Takahashi, JB Foster, CLG Lin - Cellular and Molecular Life Sciences, 2015 - Springer
Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Arundic acid increases expression and function of astrocytic glutamate transporter EAAT1 via the ERK, Akt, and NF-κB pathways
P Karki, P Hong, J Johnson, E Pajarillo, DS Son… - Molecular …, 2018 - Springer
Glutamate is the major excitatory neurotransmitter in the brain, but excessive synaptic
glutamate must be removed to prevent excitotoxic injury and death. Two astrocytic glutamate …
glutamate must be removed to prevent excitotoxic injury and death. Two astrocytic glutamate …
Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity
Excitotoxicity has been implicated as the mechanism of neuronal damage resulting from
acute insults such as stroke, epilepsy, and trauma, as well as during the progression of adult …
acute insults such as stroke, epilepsy, and trauma, as well as during the progression of adult …
Role of excitatory amino acid transporter‐2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics
Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …
EAAT2 and the molecular signature of amyotrophic lateral sclerosis
LT Rosenblum, D Trotti - Glial Amino Acid Transporters, 2017 - Springer
Amyotrophic lateral sclerosis (ALS) is a rapid and fatal neurodegenerative disease, primarily
affecting upper and lower motor neurons. It is an extremely heterogeneous disease in both …
affecting upper and lower motor neurons. It is an extremely heterogeneous disease in both …