Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population
underscores the need for broadly active countermeasures. We employed a directed …
underscores the need for broadly active countermeasures. We employed a directed …
Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
Understanding broadly neutralizing sarbecovirus antibody responses is key to developing
countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses
The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape,–, have activity
against diverse sarbecoviruses,,–, and be highly protective through viral neutralization,,–and …
against diverse sarbecoviruses,,–, and be highly protective through viral neutralization,,–and …
Broad sarbecovirus neutralization by a human monoclonal antibody
MA Tortorici, N Czudnochowski, TN Starr, R Marzi… - Nature, 2021 - nature.com
The recent emergence of SARS-CoV-2 variants of concern,,,,,,,,–and the recurrent spillovers
of coronaviruses, into the human population highlight the need for broadly neutralizing …
of coronaviruses, into the human population highlight the need for broadly neutralizing …
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site
T Onodera, S Kita, Y Adachi, S Moriyama, A Sato… - Immunity, 2021 - cell.com
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses
The devastation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has made clear the importance of pandemic preparedness. To address future zoonotic …
has made clear the importance of pandemic preparedness. To address future zoonotic …
Broad neutralization of SARS-related viruses by human monoclonal antibodies
Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs)
are urgently needed. To gain a deeper understanding of cross-neutralizing antibody …
are urgently needed. To gain a deeper understanding of cross-neutralizing antibody …
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2),
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …
A broad and potent neutralization epitope in SARS-related coronaviruses
Many neutralizing antibodies (nAbs) elicited to ancestral severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced …
coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced …