IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

X Hu, WX Peng, H Zhou, J Jiang, X Zhou… - Cell Death & …, 2020 - nature.com
The major function of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is to
regulate cell metabolism. However, emerging evidence indicates that IGF2BP2 plays a role …

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

J Wang, L Chen, P Qiang - Cancer cell international, 2021 - Springer
The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is
an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 …

IGF2BP2 regulates MALAT1 by serving as an N6-methyladenosine reader to promote NSCLC proliferation

L Han, G Lei, Z Chen, Y Zhang, C Huang… - Frontiers in molecular …, 2022 - frontiersin.org
Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is an important
posttranscriptional regulatory for stability and m6A modification. Here, we investigated the …

RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer

Z Yang, T Wang, D Wu, Z Min, J Tan, B Yu - Journal of Experimental & …, 2020 - Springer
Abstract Background N6-Methyladenosine (m6A) modification has been implicated in
multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A …

Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 …

S Huang, Z Wu, Y Cheng, W Wei… - Acta biochimica et …, 2019 - academic.oup.com
Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is a member of the IGF2BP
protein family consisting of IGF2BP1~ 3 with the capacity of binding to many transcripts and …

IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner

LJ Chen, HY Liu, ZY Xiao, T Qiu, D Zhang… - Cell Death & …, 2023 - nature.com
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is
associated with tumorigenesis and progression. However, the exact molecular mechanisms …

Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway

X Xu, Y Yu, K Zong, P Lv, Y Gu - Journal of Experimental & Clinical Cancer …, 2019 - Springer
Background The survival of pancreatic cancer patients remains poor. However, the
underlying molecular mechanism and new therapeutic target of pancreatic cancer are still …

LncRNA BCAN-AS1 stabilizes c-Myc via N6-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer

G Wu, J Su, L Zeng, S Deng, X Huang, Y Ye… - Cell Death & …, 2023 - nature.com
C-Myc overexpression contributes to multiple hallmarks of human cancer but directly
targeting c-Myc is challenging. Identification of key factors involved in c-Myc dysregulation is …

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

X Huang, H Zhang, X Guo, Z Zhu, H Cai… - Journal of hematology & …, 2018 - Springer
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in
embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner …

MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma

M Du, Y Peng, Y Li, W Sun, H Zhu, J Wu, D Zong… - Cell Death …, 2022 - nature.com
Abstract N6-Methyladenosine (m6A) modification is the most abundant RNA modification in
eukaryotic cells. IGF2BP3, a well-known m6A reader, is deregulated in many cancers, but its …