Importance Genetic studies with broad definitions of depression may not capture genetic risk
specific to major depressive disorder (MDD), raising questions about how depression …

Objective: Identifying risk factors for major depression and depressive symptoms in youths
could have important implications for prevention efforts. This study examined the association …

Background Major depressive disorder (MDD) is a leading cause of disease-associated
disability, with much of the increased burden due to psychiatric and medical comorbidity …

Background Major depressive disorder (MDD) is a common and highly heterogeneous
psychiatric disorder, but little is known about the genetic characterization of this …

Importance Although the usefulness of polygenic risk scores as a measure of genetic liability
for major depression (MD) has been established, their association with depression in the …

BackgroundMajor depressive disorder (MDD) is moderately heritable, however genome-
wide association studies (GWAS) for MDD, as well as for related continuous outcomes, have …

Background Despite moderate heritability estimates for depression‐related phenotypes, few
robust genetic predictors have been identified. Potential explanations for this discrepancy …

To identify genetic risk loci for major depressive disorder (MDD), two broad study design
approaches have been applied:(1) to maximize sample size by combining data from …

Background The genetics of depression has been explored in genome-wide association
studies that focused on either major depressive disorder or depressive symptoms with …

Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to …