The pathogenesis and treatment of theCytokine Storm'in COVID-19

Q Ye, B Wang, J Mao - Journal of infection, 2020 - Elsevier
Cytokine storm is a general term applied to maladaptive cytokine release in response to
infection and other stimuli. The pathogenesis is complex but includes loss of regulatory …

COVID-19 cytokine storm: The anger of inflammation

M Mahmudpour, J Roozbeh, M Keshavarz, S Farrokhi… - Cytokine, 2020 - Elsevier
Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a
state of out-of-control release of a variety of inflammatory cytokines. The molecular …

Coronavirus disease 2019: investigational therapies in the prevention and treatment of hyperinflammation

I Amigues, AH Pearlman, A Patel, P Reid… - Expert review of …, 2020 - Taylor & Francis
Introduction: The mortality of coronavirus disease 2019 (COVID-19) is frequently driven by
an injurious immune response characterized by the development of acute respiratory …

Storm at the time of corona: a glimpse at the current understanding and therapeutic opportunities of the SARS-CoV-2 cytokine storm

M Torabi-Rahvar, N Rezaei - Current Pharmaceutical Design, 2021 - ingentaconnect.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to severe
disease in some cases, leading to acute respiratory distress syndrome, multi-organ failure …

[HTML][HTML] Macrophage activation and cytokine release syndrome in COVID-19: current updates and analysis of repurposed and investigational anti-cytokine drugs

A Iqubal, F Hoda, AK Najmi, SE Haque - Drug Research, 2021 - thieme-connect.com
Coronavirus disease (COVID-19) emerged from Wuhan, has now become pandemic and
the mortality rate is growing exponentially. Clinical complication and fatality rate is much …

[HTML][HTML] Recent insight into SARS-CoV2 immunopathology and rationale for potential treatment and preventive strategies in COVID-19

S Lega, S Naviglio, S Volpi, A Tommasini - Vaccines, 2020 - mdpi.com
As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great
effort is being made to understand the disease pathogenesis and host factors that …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …

COVID-19: immunopathogenesis and Immunotherapeutics

L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected …

Immune dysregulation and system pathology in COVID-19

M Jamal, HI Bangash, M Habiba, Y Lei, T Xie, J Sun… - Virulence, 2021 - Taylor & Francis
ABSTRACT The coronavirus disease 19 (COVID-19) caused by the novel coronavirus
known as SARS-CoV-2 has caused a global public health crisis. As of 7 January 2021 …

Cytokine storm syndrome in SARS-CoV-2: a review

B Wahid, N Rani, M Idrees - Zeitschrift für Naturforschung C, 2022 - degruyter.com
After wreaking havoc on a global level with a total of 5,488,825 confirmed cases and
349,095 deaths as of May 2020, severe acute respiratory syndrome coronavirus 2 is truly …