Cellular signalling by SARS-CoV-2 spike protein

NP Gracie, LYS Lai, TP Newsome - Microbiology Australia, 2024 - CSIRO Publishing
Following the release of the SARS-CoV-2 genome, the spike protein was identified as the
key viral protein mediating cell entry. In addition to its critical function in delivering the viral …

The SARS-CoV-2 S1 Spike Protein Promotes MAPK and NF-kB Activation and Inflammatory Cytokine Production In Human Lung and Intestinal Epithelial Cells

CB Forsyth, L Zhang, A Bhushan, BA Swanson… - 2022 - preprints.org
Abstract The Coronavirus disease 2019 (COVID-19) pandemic began in Jan. 2020 in
Wuhan, China with a new coronavirus designated SARS-CoV-2. The principle cause of …

Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage

C Park, IY Hwang, SLS Yan, S Vimonpatranon, D Wei… - Elife, 2024 - elifesciences.org
Abstract The trimeric SARS-CoV-2 Spike protein mediates viral attachment facilitating cell
entry. Most COVID-19 vaccines direct mammalian cells to express the Spike protein or …

SARS-CoV-2 spike protein elicits cell signaling in human host cells: implications for possible consequences of COVID-19 vaccines

YJ Suzuki, SG Gychka - Vaccines, 2021 - mdpi.com
The world is suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses its …

The future of the COVID-19 pandemic: How good (or bad) can the SARS-CoV2 spike protein get?

MA Nugent - Cells, 2022 - mdpi.com
Severe acute respiratory syndrome virus 2 (SARS-CoV2) has infected an estimated 400
million people world-wide, causing approximately 6 million deaths from severe coronavirus …

SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity

G Petruk, M Puthia, J Petrlova… - Journal of Molecular …, 2020 - academic.oup.com
There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic
syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we …

[HTML][HTML] The host interactome of spike expands the tropism of SARS-CoV-2

C Bamberger, S Pankow, S Martínez-Bartolomé… - bioRxiv, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 virus causes severe acute respiratory syndrome (COVID-19) and has
rapidly created a global pandemic. Patients that survive may face a slow recovery with long …

[PDF][PDF] SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines. Vaccines 2021, 9, 36

YJ Suzuki, SG Gychka - 2021 - scienceopen.com
The world is suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses its …

Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge

C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
The global coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …

[HTML][HTML] Exploring COVID-19: Relating the spike protein to infectivity, pathogenicity and immunogenicity

V Nikhra - International Journal of Clinical Virology, 2021 - clinvirologyjournal.com
Conclusion: THE UNMET CHALLENGES: COVID-19 as a disease and SARS-CoV-2 as its
causative organism, continue to remain an enigma. While we continue to explore the agent …