G Barnes, AG Japp, DE Newby - Heart, 2010 - heart.bmj.com
Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key hormone in cardiovascular homoeostasis. It is expressed in a diverse range of tissues with …
AY Sheikh, HJ Chun, AJ Glassford… - American Journal …, 2008 - journals.physiology.org
Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …
JR Dalzell, JP Rocchiccioli, RAP Weir… - Journal of cardiac …, 2015 - Elsevier
The apelin-APJ system is a novel neurohormonal pathway, with studies to date suggesting that it may be of pathophysiologic relevance in heart failure and may indeed be a viable …
KS Chong, RS Gardner, JJ Morton… - European journal of …, 2006 - Wiley Online Library
Background: Apelin, the novel endogenous ligand for the G‐protein‐coupled receptor APJ, has shown positive inotropic, vasodilatory and diuretic properties in animal studies …
Background—Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin–angiotensin receptor-like 1 (APJ) …
B Chandrasekaran, O Dar… - European journal of heart …, 2008 - Wiley Online Library
Apelin is a novel peptide that acts through the APJ receptor, sharing similarities with the angiotensin II–angiotensin II type 1 receptor pathway. It is a peripheral vasodilator, powerful …
P Atluri, KJ Morine, GP Liao, CM Panlilio… - Cellular & molecular …, 2007 - Springer
Apelin interacts with the APJ receptor to enhance inotropy. In heart failure, apelin-APJ coupling may provide a means of enhancing myocardial function. The alterations in apelin …
Y Iwanaga, Y Kihara, H Takenaka, T Kita - Journal of molecular and cellular …, 2006 - Elsevier
Cardiac apelin has recently been suggested to contribute to the pathophysiology of heart failure (HF) in humans. In animal experiments, its infusion acutely improved systolic as well …
DN Charo, M Ho, G Fajardo… - American Journal …, 2009 - journals.physiology.org
Studies have shown significant cardiovascular effects of exogenous apelin administration, including the potent activation of cardiac contraction. However, the role of the endogenous …