[HTML][HTML] SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways
Loss of olfactory function has been commonly reported in SARS-CoV-2 infections. Recovery
from anosmia is not well understood. Previous studies showed that sustentacular cells, and …
from anosmia is not well understood. Previous studies showed that sustentacular cells, and …
Fatal neurodissemination and SARS-CoV-2 tropism in K18-hACE2 mice is only partially dependent on hACE2 expression
M Carossino, D Kenney, AK O'Connell, P Montanaro… - Viruses, 2022 - mdpi.com
Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-
CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human …
CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human …
[HTML][HTML] The spatial landscape of lung pathology during COVID-19 progression
Recent studies have provided insights into the pathology of and immune response to COVID-
19,,,,,,–. However, a thorough investigation of the interplay between infected cells and the …
19,,,,,,–. However, a thorough investigation of the interplay between infected cells and the …
A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
with millions of human infections. One limitation to the evaluation of potential therapies and …
with millions of human infections. One limitation to the evaluation of potential therapies and …
The K18-human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus
ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …
Six months of coronavirus: the mysteries scientists are still racing to solve
E Callaway, H Ledford, S Mallapaty - Nature, 2020 - nature.com
In late December 2019, reports emerged of a mysterious pneumonia in Wuhan, China, a city
of 11 million people in the southeastern province of Hubei. The cause, Chinese scientists …
of 11 million people in the southeastern province of Hubei. The cause, Chinese scientists …
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection can result in prolonged pathologies collectively referred to as post-acute sequalae …
infection can result in prolonged pathologies collectively referred to as post-acute sequalae …
How COVID-19 can damage the brain
M Marshall - Nature, 2020 - nature.com
In a June paper5, he and his team analysed clinical details for 125 people in the United
Kingdom with COVID-19 who had neurological or psychiatric effects. Of these, 62% had …
Kingdom with COVID-19 who had neurological or psychiatric effects. Of these, 62% had …
Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies
FA Lempp, LB Soriaga, M Montiel-Ruiz, F Benigni… - Nature, 2021 - nature.com
Abstract SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—
relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically …
relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically …
Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae
RC Thompson, NW Simons, L Wilkins, E Cheng… - Nature Medicine, 2023 - nature.com
Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A …
infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A …