[HTML][HTML] A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome

W Hong, J Yang, Z Bi, C He, H Lei, W Yu… - Signal transduction and …, 2021 - nature.com
The COVID-19 pandemic has covered more than 200 countries and regions around the
world since its outbreak in January 2020. To date, the SARS-CoV-2 virus has caused> 1.2 …

[HTML][HTML] Evolution of antibody immunity to SARS-CoV-2

C Gaebler, Z Wang, JCC Lorenzi, F Muecksch, S Finkin… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with …

Lung expression of human angiotensin-converting enzyme 2 sensitizes the mouse to SARS-CoV-2 infection

K Han, RV Blair, N Iwanaga, F Liu… - American journal of …, 2021 - atsjournals.org
Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …

[HTML][HTML] SARS-CoV-2 infection in K18-ACE2 transgenic mice replicates human pulmonary disease in COVID-19

VM Arce, JA Costoya - Cellular & Molecular Immunology, 2021 - nature.com
Over the last several months, a global pandemic has developed due to the emergence of the
novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is capable of …

[HTML][HTML] SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

JS Turner, W Kim, E Kalaidina, CW Goss, AM Rauseo… - Nature, 2021 - nature.com
Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of
protective antibodies 1, 2, 3, 4, 5, 6, 7. Individuals who have recovered from COVID-19 have …

[HTML][HTML] Local and systemic responses to SARS-CoV-2 infection in children and adults

M Yoshida, KB Worlock, N Huang, RGH Lindeboom… - Nature, 2022 - nature.com
It is not fully understood why COVID-19 is typically milder in children,–. Here, to examine the
differences between children and adults in their response to SARS-CoV-2 infection, we …

[HTML][HTML] Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

F Seehusen, JJ Clark, P Sharma, EG Bentley, A Kirby… - Viruses, 2022 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the
respiratory tract but also causes neurological symptoms such as loss of smell and taste …

[HTML][HTML] Prevalence of persistent SARS-CoV-2 in a large community surveillance study

M Ghafari, M Hall, T Golubchik, D Ayoubkhani, T House… - Nature, 2024 - nature.com
Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future
outbreaks,,,–, give rise to highly divergent lineages,–and contribute to cases with post-acute …

[HTML][HTML] Emerging SARS-CoV-2 variants expand species tropism to murines

H Shuai, JFW Chan, TTT Yuen, C Yoon, JC Hu… - …, 2021 - thelancet.com
Background Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-
CoV-2 variants, including B. 1.1. 7, B. 1.351, P. 1, and P. 3, contain mutations in spike that …

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

B Israelow, E Song, T Mao, P Lu, A Meir, F Liu… - Journal of Experimental …, 2020 - rupress.org
Severe acute respiratory syndrome–coronavirus 2 (SARS-Cov-2) has caused over
13,000,000 cases of coronavirus disease (COVID-19) with a significant fatality rate …