Localisation and modulation of prostanoid receptors EP1 and EP4 in the rat chronic constriction injury model of neuropathic pain
PL Woodhams, RE MacDonald, SD Collins… - European Journal of …, 2007 - Elsevier
Immunohistochemistry was used to examine the expression of prostaglandin E2 receptors
EP1 and EP4 in sciatic nerves from the rat chronic constriction injury (CCI) model of …
EP1 and EP4 in sciatic nerves from the rat chronic constriction injury (CCI) model of …
Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study
PF Durrenberger, P Facer, MA Casula, Y Yiangou… - BMC neurology, 2006 - Springer
Background Recent studies show that inflammatory processes may contribute to
neuropathic pain. Cyclooxygenase-2 (Cox-2) is an inducible enzyme responsible for …
neuropathic pain. Cyclooxygenase-2 (Cox-2) is an inducible enzyme responsible for …
Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation
W Ma, JC Eisenach - Experimental neurology, 2003 - Elsevier
We previously reported that cyclooxygenase 2 (COX2) is up-regulated in macrophages in
injured nerve of rats with partial sciatic nerve ligation (PSNL) and that local injection of the …
injured nerve of rats with partial sciatic nerve ligation (PSNL) and that local injection of the …
Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
W Ma, JC Eisenach - European Journal of Neuroscience, 2002 - Wiley Online Library
Inflammatory mediators produced in the injured nerve have been proposed as contributing
factors in the development of neuropathic pain. Prostaglandins (PGs) are probably included …
factors in the development of neuropathic pain. Prostaglandins (PGs) are probably included …
Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor α3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain …
K Hösl, H Reinold, RJ Harvey, U Müller, S Narumiya… - Pain, 2006 - Elsevier
Inflammation, peripheral nerve injury and chemical irritants can cause central sensitization
in pain pathways. Prostaglandins produced in the CNS induce central sensitization during …
in pain pathways. Prostaglandins produced in the CNS induce central sensitization during …
Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal …
B St-Jacques, W Ma - Experimental neurology, 2014 - Elsevier
Abstract Prostaglandin E2 (PGE2), a well-known pain mediator enriched in inflamed tissues,
plays a pivotal role in the genesis of chronic pain conditions such as inflammatory and …
plays a pivotal role in the genesis of chronic pain conditions such as inflammatory and …
Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain
T Johansson, S Narumiya, HU Zeilhofer - Neuroscience letters, 2011 - Elsevier
Abstract Prostaglandin E 2 (PGE 2) is a key mediator of exaggerated pain sensation during
inflammation. Drugs targeting the PGE 2 pathway by global inhibition of cyclooxygenases …
inflammation. Drugs targeting the PGE 2 pathway by global inhibition of cyclooxygenases …
Neuronal prostaglandin E2 receptor subtype EP3 mediates antinociception during inflammation
G Natura, KJ Bär, A Eitner… - Proceedings of the …, 2013 - National Acad Sciences
The pain mediator prostaglandin E2 (PGE2) sensitizes nociceptive pathways through EP2
and EP4 receptors, which are coupled to Gs proteins and increase cAMP. However, PGE2 …
and EP4 receptors, which are coupled to Gs proteins and increase cAMP. However, PGE2 …
The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage
EM Treutlein, K Kern, A Weigert, N Tarighi… - Journal of Biological …, 2018 - ASBMB
Prostaglandin (PG) E 2 is an important lipid mediator that is involved in several
pathophysiological processes contributing to fever, inflammation, and pain. Previous studies …
pathophysiological processes contributing to fever, inflammation, and pain. Previous studies …
Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain
Abstract Prostaglandin E2 (PGE2) is a lipid mediator which plays a role in the generation of
inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes …
inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes …