Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding
Elicitation of broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal. Native-
like trimers mimicking virion-associated spikes present nearly all bnAb epitopes and are …
like trimers mimicking virion-associated spikes present nearly all bnAb epitopes and are …
Structure-based design of a soluble prefusion-closed HIV-1 Env trimer with reduced CD4 affinity and improved immunogenicity
ABSTRACT The HIV-1 envelope (Env) trimer is a target for vaccine design as well as a
conformational machine that facilitates virus entry by transitioning between prefusion-closed …
conformational machine that facilitates virus entry by transitioning between prefusion-closed …
HIV-1 envelope trimer design and immunization strategies to induce broadly neutralizing antibodies
SW de Taeye, JP Moore, RW Sanders - Trends in immunology, 2016 - cell.com
The identification of multiple broadly neutralizing antibodies (bNAbs) against the HIV-1
envelope glycoprotein (Env) trimer has facilitated its structural characterization and guided …
envelope glycoprotein (Env) trimer has facilitated its structural characterization and guided …
HIV-1 neutralizing antibody signatures and application to epitope-targeted vaccine design
Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for
vaccine development, and the potential of passively delivered bNAbs for prophylaxis and …
vaccine development, and the potential of passively delivered bNAbs for prophylaxis and …
Rational design of DNA-expressed stabilized native-like HIV-1 envelope trimers
Summary The HIV-1-envelope glycoprotein (Env) is the main target of antigen design for
antibody-based prophylactic vaccines. The generation of broadly neutralizing antibodies …
antibody-based prophylactic vaccines. The generation of broadly neutralizing antibodies …
Interdomain stabilization impairs CD4 binding and improves immunogenicity of the HIV-1 envelope trimer
Summary The HIV-1 envelope (Env) spike is a trimer of gp120/gp41 heterodimers that
mediates viral entry. Binding to CD4 on the host cell membrane is the first essential step for …
mediates viral entry. Binding to CD4 on the host cell membrane is the first essential step for …
Structure‐guided envelope trimer design in HIV‐1 vaccine development: a narrative review
R Derking, RW Sanders - Journal of the International AIDS …, 2021 - Wiley Online Library
Introduction The development of a human immunodeficiency virus 1 (HIV‐1) vaccine
remains a formidable challenge. An effective vaccine likely requires the induction of broadly …
remains a formidable challenge. An effective vaccine likely requires the induction of broadly …
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies
CC LaBranche, R Henderson, A Hsu, S Behrens… - PLoS …, 2019 - journals.plos.org
The CD4 binding site (CD4bs) of the HIV-1 envelope glycoprotein is susceptible to multiple
lineages of broadly neutralizing antibodies (bnAbs) that are attractive to elicit with vaccines …
lineages of broadly neutralizing antibodies (bnAbs) that are attractive to elicit with vaccines …
Native‐like Env trimers as a platform for HIV‐1 vaccine design
RW Sanders, JP Moore - Immunological reviews, 2017 - Wiley Online Library
We describe the development and potential use of various designs of recombinant HIV‐1
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …
Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer
The trimeric envelope (Env) spike is the focus of vaccine design efforts aimed at generating
broadly neutralizing antibodies (bNAbs) to protect against HIV-1 infection. Three recent …
broadly neutralizing antibodies (bNAbs) to protect against HIV-1 infection. Three recent …