Although interferon-γ (IFN-γ) induces the transporter associated with antigen processing
(Tap)-1 expression in macrophages, cooperation with lipopolysaccharide signaling through …

With recent studies suggesting a key role for professional antigen presenting cells in the
induction of major histocompatibility class I cellular immune responses, we initiated studies …

Transporter associated with Ag processing 1 and low molecular mass polypeptide 2 (LMP2)
are essential for class I MHC function and share a common bidirectional promoter. In murine …

The genes of the transporter associated with antigen processing (Tap)-1, and the low
molecular weight peptide (Lmp)-2, are crucial for class I major histocompatibility complex …

Proper regulation of the Tap-1 gene is critical for the initiation and continuation of a cellular
immune response. Analysis of the Tap-1/low molecular mass polypeptide 2 bidirectional …

Treatment of macrophages with lipopolysaccharide (LPS) from Gram-negative bacteria or
peptidoglycan (PGN) from Gram-positive bacteria activates multiple intracellular signaling …

Activator protein 1 (AP-1) binds to the promoters of many genes involved in immune and
inflammatory responses. We have previously shown that the p38 mitogen-activated protein …

Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor
protein that contains pleckstrin and Src homology 2-like domains as well as a YXXQ motif in …

In human monocytes and macrophages, interferon-γ (IFNγ) augmented mRNA and surface
expression of toll-like receptor 4 (TLR4), a crucial component of the signaling receptor …

Signal transducing adaptor protein‐2 (STAP‐2) is a recently identified adaptor protein, that
contains pleckstrin and Src homology 2 (SH2)‐like domains as well as a YXXQ motif in its C …