Although over 35 different histone acetylation marks have been described, the
overwhelming majority of regulatory genomics studies focus exclusively on H3K27ac and …

Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

H3K27ac is well recognized as a marker for active enhancers and a great indicator of
enhancer activity. However, its functional impact on transcription has not been …

Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

Background Transcription regulation in pluripotent embryonic stem (ES) cells is a complex
process that involves multitude of regulatory layers, one of which is post-translational …

Histone acetylation is generally associated with gene activation and chromatin
decondensation. Recent mass spectrometry analysis has revealed that histone H4 lysine 20 …

Specific chromatin features, especially histone H3 lysine 27 acetylation, are widely used to
identify active enhancers, yet current methods are imprecise. New work suggests that …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …

Comparative genomic studies have been useful in identifying transcriptional regulatory
elements in higher eukaryotic genomes, but many important regulatory elements cannot be …

Background Histone post-translational modifications are critical determinants of chromatin
structure and function, impacting multiple biological processes including DNA transcription …