Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …

Bidirectional interactions between the immune system and the nervous system are
increasingly appreciated as playing a pathogenic role in chronic pain. Unraveling the …

Pain is one of the most debilitating symptoms of rheumatoid arthritis (RA), and yet remains
poorly understood, especially when pain occurs in the absence of synovitis. Without active …

Chronic neuropathic and inflammatory pain is a major public health problem. Nociceptors
undergo sensitization, first in peripheral tissues then in the central nervous sytem, via …

Pain is the leading symptom for most individuals with osteoarthritis (OA), a complex
condition marked by joint discomfort. Recently, the dynamic interplay between the nervous …

The growing awareness of the critical role played by the innate and adaptive immune
systems in the mechanisms underlying chronic pain has prompted further research …

Chronic pain associated with joint disorders, such as rheumatoid arthritis (RA), osteoarthritis
(OA) and implant aseptic loosening (AL), is a highly debilitating symptom that impacts …

Chronic pain, differently from nociceptive pain, results from a maladaptive response of the
body. Accumulating evidence shows that the mechanism of persistent pathological pain is …

Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory
mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types …

In this narrative review, we discuss the emerging role of innate immunity in osteoarthritis
(OA) joint pain. First, we give a brief description of the pain pathway in the context of OA …