Severe COVID-19 associated respiratory failure, poses the one challenge of our days.
Assessment and treatment of COVID-19 associated hyperinflammation may be key to …

COVID-19 or SARS-CoV-2 infection can lead to severe acute respiratory distress
syndrome/pneumonia with features of cytokine storm reminiscent of secondary …

Interventions: A treatment regimen of methylprednisolone, pentaglobin, and anakinra was
developed and administered. Outcomes: One patient survived the ICU stay. Two other …

Background COVID-19, a disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), commonly presents as fever, cough, dyspnea, and myalgia or …

Cytokine storm is an umbrella term that describes an inflammatory syndrome characterized
by elevated levels of circulating cytokines and hyperactivation of innate and/or adaptive …

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has resulted in significant morbidity and mortality …

Background Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening
hyperinflammatory event and a fatal complication of viral infections. Whether sHLH may also …

The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has
parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based …

A previously healthy 55-year-old woman presented with fever, malaise, and a mild cough.
Chest radiograph revealed bilateral patchy infiltrates. A nasopharyngeal swab tested …

Dysregulation of inflammation is hypothesized to play a crucial role in the severe
complications of COVID-19, with the IL-1/IL-6 pathway being central. Here, we report on the …