Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus

F Soriguer, L Garrido-Sanchez, S Garcia-Serrano… - Obesity surgery, 2009 - Springer
Background The physiological role of apelin in obesity and diabetes remains unclear.
Although apelin has been studied in persons with different conditions, no studies have yet …

Altered glucose homeostasis is associated with increased serum apelin levels in type 2 diabetes mellitus

MG Cavallo, F Sentinelli, I Barchetta, C Costantino… - PloS one, 2012 - journals.plos.org
Background Apelin is an adipokine that plays a role in the regulation of glucose
homeostasis and in obesity. The relationship between apelin serum concentration and …

Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus

G Erdem, T Dogru, I Tasci, A Sonmez… - Experimental and …, 2008 - thieme-connect.com
Objective: To investigate blood apelin concentrations in patients with newly diagnosed and
untreated type 2 diabetes mellitus (T2DM) who had no additional disorder and to investigate …

[HTML][HTML] Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity

J Krist, K Wieder, N Klöting, A Oberbach, S Kralisch… - Obesity facts, 2013 - karger.com
Objective: Apelin is an adipokine which plays a role in the regulation of glucose
homeostasis and may contribute to the link between increased adipose tissue mass and …

Circulating a pelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control

M Habchi, L Duvillard, V Cottet, MC Brindisi… - Clinical …, 2014 - Wiley Online Library
Context Apelin is an adipokine expressed in several tissues and it appears to be involved in
energy metabolism. Objective The aim of this study was to determine serum apelin levels in …

Plasma apelin is lower in patients with elevated LDL-cholesterol

I Tasci, T Dogru, I Naharci, G Erdem… - Experimental and …, 2007 - thieme-connect.com
Hypercholesterolemia is a major risk factor for atherosclerosis. Dysregulation of adipokines
contribute to atherosclerotic diseases. Apelin has recently been shown to be secreted by the …

Plasma apelin: a novel biomarker for predicting diabetes

WY Ma, TY Yu, JN Wei, CS Hung, MS Lin, YJ Liao… - Clinica chimica acta, 2014 - Elsevier
Background Apelin regulates insulin sensitivity and secretion in animals. However, whether
plasma apelin predicts incident diabetes in humans remains unknown. Methods We studied …

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

C Dray, C Debard, J Jager, E Disse… - American journal …, 2010 - journals.physiology.org
Apelin, an adipocyte-secreted factor upregulated by insulin, is increased in adipose tissue
(AT) and plasma with obesity. Apelin was recently identified as a new player in the control of …

Elevated plasma levels of apelin in children with type 1 diabetes mellitus

C Meral, E Tascilar, F Karademir, IA Tanju, F Cekmez… - 2010 - degruyter.com
Background: Apelin is a novel adipocytokine produced by white adipose tissue that binds
the APJ receptor with high affinity. Insulin may have a role in regulation of apelin synthesis …

Apelin, a newly identified adipokine up-regulated by insulin and obesity

J Boucher, B Masri, D Daviaud, S Gesta… - …, 2005 - academic.oup.com
The results presented herein demonstrate that apelin is expressed and secreted by both
human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other …