Metazoan transcription is controlled through either coordinated recruitment of transcription
machinery to the gene promoter or regulated pausing of RNA polymerase II (Pol II) in early …

Many biological processes are controlled, spatially and temporally, at the level of
transcription. Thus, understanding the mechanisms of transcriptional regulation of gene …

The Mediator complex directs signals from DNA-binding transcription factors to RNA
polymerase II (Pol II). Despite this pivotal position, mechanistic understanding of Mediator in …

The current view of gene regulation in complex organisms holds that gene expression is
largely controlled by the combinatoric actions of transcription factors and other regulatory …

Abstract Eukaryotic RNA polymerase II (Pol II) has been found at both promoters and distal
enhancers, suggesting additional functions beyond mRNA production. To understand this …

Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Downstream core promoter elements are an expanding class of regulatory sequences that
add considerable diversity to the promoter architecture of RNA polymerase II-transcribed …

The core promoter compositions of mammalian protein-coding genes are highly variable;
some contain TATA boxes, some contain initiator (Inr) elements, and others contain both or …

The Mediator complex associates with eukaryotic RNA polymerase (Pol) II and is recruited to
transcriptional enhancers by activator proteins. It is believed that Mediator is a general …

The binding of transcription regulators to cis-regulatory sequences is a key step through
which all cells regulate expression of their genes. Due to gains and losses of cis-regulatory …