The ground state and evolution of promoter region directionality
Eukaryotic promoter regions are frequently divergently transcribed in vivo, but it is unknown
whether the resultant antisense RNAs are a mechanistic by-product of RNA polymerase II …
whether the resultant antisense RNAs are a mechanistic by-product of RNA polymerase II …
Transcription regulation at the core: similarities among bacterial, archaeal, and eukaryotic RNA polymerases
KB Decker, DM Hinton - Annual review of microbiology, 2013 - annualreviews.org
Multisubunit RNA polymerases are complex protein machines that require a specificity factor
for the recognition of a specific transcription start site. Although bacterial σ factors are …
for the recognition of a specific transcription start site. Although bacterial σ factors are …
New problems in RNA polymerase II transcription initiation: matching the diversity of core promoters with a variety of promoter recognition factors
The regulatory significance of the above described diversity of core promoters is not yet
resolved. In the simplest scenario, distinct core promoter elements would create binding …
resolved. In the simplest scenario, distinct core promoter elements would create binding …
[HTML][HTML] A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2
P Hu, S Wu, N Hernandez - Molecular cell, 2003 - cell.com
In higher eukaryotes, RNA polymerase (pol) III is known to use different transcription factors
to recognize three basic types of promoters, but in no case have these transcription factors …
to recognize three basic types of promoters, but in no case have these transcription factors …
Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit
The evolutionarily conserved Mediator complex is a critical coactivator for RNA polymerase
II (Pol II)-mediated transcription. Here we report the reconstitution of a functional 15-subunit …
II (Pol II)-mediated transcription. Here we report the reconstitution of a functional 15-subunit …
The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes
ST Smale, A Jain, J Kaufmann… - Cold Spring Harbor …, 1998 - symposium.cshlp.org
Cold Spring Harbor Symposia on Quantitative Biology, Volume LXIII.© 1998 Cold Spring
Harbor Laboratory Press 0-87969-550-1/98. 21 that functions only in cooperation with a …
Harbor Laboratory Press 0-87969-550-1/98. 21 that functions only in cooperation with a …
Genomic environments scale the activities of diverse core promoters
CKY Hong, BA Cohen - Genome research, 2022 - genome.cshlp.org
A classical model of gene regulation is that enhancers provide specificity whereas core
promoters provide a modular site for the assembly of the basal transcriptional machinery …
promoters provide a modular site for the assembly of the basal transcriptional machinery …
Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation
RR Catarino, A Stark - Genes & development, 2018 - genesdev.cshlp.org
Enhancers are important genomic regulatory elements directing cell type-specific
transcription. They assume a key role during development and disease, and their …
transcription. They assume a key role during development and disease, and their …
Reconstruction of the core and extended regulons of global transcription factors
The processes underlying the evolution of regulatory networks are unclear. To address this
question, we used a comparative genomics approach that takes advantage of the large …
question, we used a comparative genomics approach that takes advantage of the large …