Circadian rhythm describes the 24-h oscillation in physiology and behavior of living
organisms and presents a timing controller for life activity. Studies in recent years have …

The circadian clock refers to the inherent biological rhythm of an organism, which, is
accurately regulated by numerous clock genes. Studies in recent years have reported that …

There is accumulating evidence for a link between circadian clock disruption and cancer
progression. In this study, the circadian clock was investigated in cervical and esophageal …

The clock gene machinery controls cellular metabolism, proliferation, and key functions,
such as DNA damage recognition and repair. Dysfunction of the circadian clock is involved …

It has been proposed that the circadian rhythm generally plays important roles in tumor
suppression, but there is also evidence that disruption of the canonical circadian pathway …

Circadian rhythms are fundamental biological systems in most organisms. Epidemiological
and animal studies have demonstrated that disruption of circadian rhythms is linked to tumor …

The circadian timing system controls about 40% of the transcriptome and is important in the
regulation of a wide variety of biological processes including metabolic and proliferative …

Background Gastric cancer (GC), an aggressive malignant tumor of the alimentary tract, is a
leading cause of cancer-related death. Circadian rhythm exhibits a 24-hour variation in …

Circadian clock genes regulate 10–15% of the transcriptome, and might function as tumor
suppressor genes. Relatively little is known about the circadian clock in tumors and its effect …

Recent evidence supports the important role of the circadian system in cancer progression
in humans. The aim of the present study is to evaluate clock (cry1, cry2 and per2) and clock …