Microvascular alterations in Alzheimer's disease

J Steinman, HS Sun, ZP Feng - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder associated with continual decline
in cognition and ability to perform routine functions such as remembering familiar places or …

Dissecting the contribution of vascular alterations and aging to Alzheimer's disease

C Janota, CA Lemere, MA Brito - Molecular neurobiology, 2016 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline
that afflicts as many as 45% of individuals who survive past the age of 85. AD has been …

Alzheimer's disease: the link between amyloid-β and neurovascular dysfunction

E Solis Jr, KN Hascup… - Journal of Alzheimer's …, 2020 - content.iospress.com
While prevailing evidence supports that the amyloid cascade hypothesis is a key component
of Alzheimer's disease (AD) pathology, many recent studies indicate that the vascular …

New therapeutic targets in the neurovascular pathway in Alzheimer's disease

BV Zlokovic - Neurotherapeutics, 2008 - Springer
Recent findings indicate that neurovascular dysfunction is an integral part of Alzheimer's
disease (AD). Changes in the vascular system of the brain may significantly contribute to the …

Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease

R Apátiga-Pérez, LO Soto-Rojas… - Metabolic brain …, 2022 - Springer
Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive
functions and short-term memory. AD patients present two distinctive neuropathological …

Vascular dysfunction—the disregarded partner of Alzheimer's disease

MD Sweeney, A Montagne, AP Sagare, DA Nation… - Alzheimer's & …, 2019 - Elsevier
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …

Cerebrovascular phenotypes in mouse models of Alzheimer's disease

JI Szu, A Obenaus - Journal of Cerebral Blood Flow & …, 2021 - journals.sagepub.com
Alzheimer's disease (AD) is a devastating neurological degenerative disorder and is the
most common cause of dementia in the elderly. Clinically, AD manifests with memory and …

Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease

AP Sagare, RD Bell, BV Zlokovic - Journal of Alzheimer's …, 2013 - content.iospress.com
The evidence that neurovascular dysfunction is an integral part of Alzheimer's disease (AD)
pathogenesis has continued to emerge in the last decade. Changes in the brain vasculature …

Morphological and pathological evolution of the brain microcirculation in aging and Alzheimer's disease

JM Hunter, J Kwan, M Malek-Ahmadi, CL Maarouf… - PloS one, 2012 - journals.plos.org
Key pathological hallmarks of Alzheimer's disease (AD), including amyloid plaques, cerebral
amyloid angiopathy (CAA) and neurofibrillary tangles do not completely account for …

Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?

ZZ Chong, F Li, K Maiese - Current neurovascular research, 2005 - ingentaconnect.com
Alzheimer's disease is a progressive disorder that results in the loss of cognitive function
and memory. Although traditionally defined by the presence of extracellular plaques of …