[HTML][HTML] Elevated inflammatory status and increased risk of chronic disease in chronological aging: inflamm-aging or inflamm-inactivity?

MG Flynn, MM Markofski, AE Carrillo - Aging and disease, 2019 - ncbi.nlm.nih.gov
Age-associated hyper-inflammation or “inflamm-aging” has been linked to the development
of chronic diseases and characterized as an unavoidable aspect of aging. However, the …

Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

C Franceschi, J Campisi - Journals of Gerontology Series A …, 2014 - academic.oup.com
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon
has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both …

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

L Ferrucci, E Fabbri - Nature Reviews Cardiology, 2018 - nature.com
Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

[HTML][HTML] Source of chronic inflammation in aging

F Sanada, Y Taniyama, J Muratsu, R Otsu… - Frontiers in …, 2018 - frontiersin.org
Aging is a complex process that results from a combination of environmental, genetic, and
epigenetic factors. A chronic pro-inflammatory status is a pervasive feature of aging. This …

Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing …

G Candore, C Caruso, E Jirillo… - Current …, 2010 - ingentaconnect.com
Nowadays, people are living much longer than they used to do, however they are not free
from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and …

[HTML][HTML] Inflammation in aging: cause, effect, or both?

NS Jenny - Discovery medicine, 2012 - discoverymedicine.com
Aging is a progressive degenerative process tightly integrated with inflammation. Cause and
effect are not clear. A number of theories have been developed that attempt to define the …

Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches

E Cevenini, C Caruso, G Candore… - Current …, 2010 - ingentaconnect.com
A typical feature of ageing is a chronic, low-grade inflammation characterized by a general
increase in the production of proinflammatory cytokines and inflammatory markers (“inflamm …

Age-associated chronic diseases require age-old medicine: role of chronic inflammation

S Prasad, B Sung, BB Aggarwal - Preventive medicine, 2012 - Elsevier
Most chronic diseases—such as cancer, cardiovascular disease (CVD), Alzheimer disease,
Parkinson disease, arthritis, diabetes and obesity—are becoming leading causes of …

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

L Liberale, F Montecucco, JC Tardif… - European heart …, 2020 - academic.oup.com
The ongoing worldwide increase in life expectancy portends a rising prevalence of age-
related cardiovascular (CV) diseases in the coming decades that demands a deeper …