Metallo-β-lactamases are zinc-dependent enzymes responsible for resistance to β-lactam
antibiotics in a variety of host bacteria, usually Gram-negative species that act as opportunist …

This past year has produced determinations of X-ray crystal structures for three metallo-β-
lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc …

Metallo-β-lactamases are a subset of zinc hydrolases able to hydrolyze the β-lactam ring of
several antibiotics. The number of structural and mechanistic studies on these …

Class B β‐lactamases or metallo‐β‐lactamases (MBLs) require zinc ions to catalyse the
hydrolysis of β‐lactam antibiotics such as penicillins, cephalosporins, carbapenems, and …

Metallo-β-lactamases are important as a major source of resistance of pathogenic bacteria
to the widely used β-lactam antibiotics. They show considerable diversity in terms of …

Metallo-β-lactamases are broad-spectrum zinc enzymes, able to inactivate most clinically
useful β-lactam antibiotics. Their structural and functional diversity has thus far limited the …

Subclass B1 β-lactamases are Zn (II)-dependent hydrolases that confer bacterial resistance
to most clinically useful β-lactam antibiotics. The enzyme BcII from Bacillus cereus is a …

β‐Lactam antibiotics are the most commonly used antibacterial agents and growing
resistance to these drugs is a concern. Metallo‐β‐lactamases are a diverse set of enzymes …

In an effort to probe the role of the Zn (II) sites in metallo-β-lactamase L1, mononuclear metal
ion containing and heterobimetallic analogues of the enzyme were generated and …

One strategy employed by bacterial strains to resist β-lactam antibiotics is the expression of
metallo-β-lactamases requiring Zn2+ for activity. In the last few years, many new zinc β …