Interleukin-I (IL-1) is the prototypic pro-inflammatory cytokine. There are two forms of IL-1, IL-
1α and IL-Iβ and in most studies, their biological activities are indistinguishable. IL-1 affects …

IL-1 (IL-1α or IL-1β) is the prototypic “multifunctional” cytokine. Unlike the lymphocyte and
colony stimulating growth factors, IL-1 affects nearly every cell type, and often in concert with …

Interleukin-1 (IL-1) is primarily an inflammatory cytokine. Biologically, IL-1 is more closely
related to tumor necrosis factor (TNF) than any other cytokine or interleukin, although the …

The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one
of the most extensively studied cytokines. Here we present a broad overview of IL-2 history …

Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …

More than any other cytokine family, the IL-1 family of ligands and receptors is primarily
associated with acute and chronic inflammation. The cytosolic segment of each IL-1 receptor …

To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in disease,
investigators have studied how production of the different members of the IL-1 family is …

Interleukin 2 (IL‐2) was one of the first cytokines to be discovered. However, the complex
role of IL‐2 and its receptor in the regulation of immune responses is only now emerging …

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …

The interleukin 1 (IL-1) receptor is a critical component in mediating the inflammatory
responses of IL-1, which affect nearly every cell type. Recently, major inroads have been …