Modulation of Covid‐19 cytokine storm by tocilizumab

A Boretti, B Banik - Journal of Medical Virology, 2022 - Wiley Online Library
Abstract Coronavirus disease 2019 (Covid‐19) is the illness caused by severe acute
respiratory syndrome coronavirus 2, first identified in Wuhan, China at the end of 2019. On …

[PDF][PDF] The effect of tocilizumab on severe COVID-19 infection: Review of current evidence

A Cemal, H İNÖNÜ - Tuberk Toraks, 2021 - tuberktoraks.org
The COVID-19 outbreak that spread in December 2019 has caused the death of millions of
people in a short time. Many studies published recently have shown that many cytokines …

Systematic review on treatment trials of tocilizumab: a repurposing drug against COVID-19

S Banerjee, AK Mahapatra - Reviews on Recent Clinical Trials, 2021 - ingentaconnect.com
Background: Coronavirus disease (COVID-19) caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) has become a global issue today. There exists an …

[HTML][HTML] Tocilizumab and COVID-19: timing of administration and efficacy

E Abidi, WS El Nekidy, E Alefishat, N Rahman… - Frontiers in …, 2022 - frontiersin.org
Elevated concentrations of interleukin-6 have been demonstrated to be an important key
factor in COVID-19 host immune impairment. It represents an important prognostic factor of …

[HTML][HTML] Rational use of tocilizumab in the treatment of novel coronavirus pneumonia

S Zhang, L Li, A Shen, Y Chen, Z Qi - Clinical drug investigation, 2020 - Springer
Since December 2019, a novel coronavirus pneumonia (COVID-19) has broken out in
Wuhan, China and spread rapidly. Recent studies have found that⁓ 15.7% of patients …

[HTML][HTML] Why tocilizumab could be an effective treatment for severe COVID-19?

B Fu, X Xu, H Wei - Journal of translational medicine, 2020 - Springer
A severe pneumonia-associated respiratory syndrome caused by a new coronavirus was
identified in December 2019 (COVID-19), spread rapidly and has become a world-wide …

[HTML][HTML] Clinical efficacy of tocilizumab treatment in severe and critical COVID-19 patients

J Zeng, MH Xie, J Yang, SW Chao… - World Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
BACKGROUND The main pathophysiological basis of coronavirus disease 2019 (COVID-
19) causing respiratory failure is a cytokine storm and interleukin-6 (IL-6) is an important …

Tocilizumab for the treatment of severe coronavirus disease 2019

R Alattar, TBH Ibrahim, SH Shaar… - Journal of medical …, 2020 - Wiley Online Library
Abstract Tocilizumab, an interleukin‐6 inhibitor, may ameliorate the inflammatory
manifestations associated with severe coronavirus disease 2019 (COVID‐19) and thus …

[HTML][HTML] Tocilizumab as treatment for COVID-19: a systematic review and meta-analysis

F Petrelli, S Cherri, M Ghidini, G Perego… - World Journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND The majority of patients with coronavirus disease 2019 (COVID-19) have
good prognoses, but some develop a critical illness that can lead to death. Evidence shows …

[HTML][HTML] Repurposed tocilizumab in patients with severe COVID-19

J Tian, M Zhang, M Jin, F Zhang, Q Chu… - The Journal of …, 2021 - journals.aai.org
The coronavirus disease 2019 (COVID-19) has caused a global pandemic, resulting in
considerable morbidity and mortality. Tocilizumab, an inhibitor of IL-6, has been widely …