A comprehensive review of tocilizumab in COVID‐19 acute respiratory distress syndrome

S Khiali, E Khani… - The Journal of Clinical …, 2020 - Wiley Online Library
Currently, the world is facing the pandemic of a novel strain of beta‐coronavirus known as
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Acute respiratory distress …

Early clinical outcomes with tocilizumab for severe COVID-19: a two-centre retrospective study

SM Smoke, K Raja, P Hilden, NM Daniel - International journal of …, 2021 - Elsevier
Abstract Severe COVID-19 (coronavirus disease 2019) is associated with elevated
inflammatory markers, consistent with cytokine release syndrome (CRS). Tocilizumab is an …

Impact of tocilizumab administration on mortality in severe COVID-19

A Tsai, O Diawara, RG Nahass, L Brunetti - Scientific reports, 2020 - nature.com
The novel coronavirus disease 2019 (COVID-19) worldwide pandemic has placed a
significant burden on hospitals and healthcare providers. The immune response to this …

[HTML][HTML] Optimal use of tocilizumab for severe and critical COVID-19: a systematic review and meta-analysis

CW Nugroho, SD Suryantoro, Y Yuliasih… - …, 2021 - ncbi.nlm.nih.gov
Background: Several studies have revealed the potential use of tocilizumab in treating
COVID-19 since no therapy has yet been approved for COVID-19 pneumonia. Tocilizumab …

Treatment with tocilizumab for patients with COVID‐19 infections: a case‐series study

Y Mo, O Adarkwah, J Zeibeq, E Pinelis… - The Journal of …, 2021 - Wiley Online Library
Tocilizumab (TCZ), a humanized monoclonal antibody targeting the interleukin‐6 receptor,
holds the potential for treating coronavirus disease 2019 (COVID‐19) patients, particularly …

Tocilizumab for the treatment of adult patients with severe COVID‐19 pneumonia: a single‐center cohort study

M Fernández‐Ruiz, F López‐Medrano… - Journal of medical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) can lead to a massive cytokine release. The
use of the anti‐interleukin‐6 receptor monoclonal antibody tocilizumab (TCZ) has been …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis, first update

IM Tleyjeh, Z Kashour, M Riaz, L Hassett… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

Clinical characteristics and early outcomes in patients with COVID-19 treated with tocilizumab at a United States academic center

CA Rimland, CE Morgan, GJ Bell, MK Kim, T Hedrick… - Medrxiv, 2020 - medrxiv.org
Limited evidence is available to guide treatment of coronavirus disease 2019 (COVID-19),
caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A …

Efficacy and safety of tocilizumab treatment COVID-19 patients: A case-control study and meta-analysis

W Jiang, W Li, Q Wu, Y Han, J Zhang, T Luo… - Infectious Diseases and …, 2021 - Springer
Introduction As the pandemic progresses, the pathophysiology of COVID-19 is becoming
more apparent, and the potential for tocilizumab is increasing. However, the clinical efficacy …

Factors predicting poor outcomes of patients treated with tocilizumab for COVID‑19‑associated pneumonia: A retrospective study

VE Georgakopoulou, D Basoulis… - Experimental and …, 2022 - spandidos-publications.com
The severe acute respiratory syndrome coronavirus‑2 (SARS‑CoV‑2) pandemic is a
significant global issue that has major implications for the healthcare system. The mortality …