Exosomes as therapeutics: the implications of molecular composition and exosomal heterogeneity

SW Ferguson, J Nguyen - Journal of Controlled Release, 2016 - Elsevier
Harnessing exosomes as therapeutic drug delivery vehicles requires a better understanding
of exosomal composition and their mode of action. A full appreciation of all the exosomal …

Exosomes as naturally occurring vehicles for delivery of biopharmaceuticals: insights from drug delivery to clinical perspectives

A Butreddy, N Kommineni, N Dudhipala - Nanomaterials, 2021 - mdpi.com
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

Exosome mimetics: a novel class of drug delivery systems

SAA Kooijmans, P Vader… - International journal …, 2012 - Taylor & Francis
The identification of extracellular phospholipid vesicles as conveyors of cellular information
has created excitement in the field of drug delivery. Biological therapeutics, including short …

Possibility of exosome-based therapeutics and challenges in production of exosomes eligible for therapeutic application

T Yamashita, Y Takahashi, Y Takakura - … and Pharmaceutical Bulletin, 2018 - jstage.jst.go.jp
Exosomes are cell-derived vesicles with a diameter 30–120 nm. Exosomes contain
endogenous proteins and nucleic acids; delivery of these molecules to exosome-recipient …

Exosomes as new generation vehicles for drug delivery: biomedical applications and future perspectives

A Rajput, A Varshney, R Bajaj, V Pokharkar - Molecules, 2022 - mdpi.com
Currently, particular interest among the scientific community is focused on exploring the use
of exosomes for several pharmaceutical and biomedical applications. This is due to the …

Exosomes: Nanoparticulate tools for RNA interference and drug delivery

F Shahabipour, N Barati, TP Johnston… - Journal of cellular …, 2017 - Wiley Online Library
Exosomes are naturally occurring extracellular vesicles released by most mammalian cells
in all body fluids. Exosomes are known as key mediators in cell‐cell communication and …

[PDF][PDF] Functions and application of exosomes

J Qin, Q Xu - Acta Pol Pharm, 2014 - ptfarm.pl
The cells continuously secrete a large number of different types of microvesicles including
macroand micro-molecules into the extracellular fluids. One of them are exosomes, which …

From structures to functions: insights into exosomes as promising drug delivery vehicles

J Ren, W He, L Zheng, H Duan - Biomaterials science, 2016 - pubs.rsc.org
Exosomes are small membrane vesicles secreted by most cell types, and appear
ubiquitously in cell culture supernatants and body fluids. Increasing evidence supports that …

Pharmacokinetics of exosomes—an important factor for elucidating the biological roles of exosomes and for the development of exosome-based therapeutics

M Morishita, Y Takahashi, M Nishikawa… - Journal of …, 2017 - Elsevier
Exosomes are small membrane vesicles containing lipids, proteins, and nucleic acids.
Recently, researchers have uncovered that exosomes are involved in various biological …

Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake

I Kimiz-Gebologlu, SS Oncel - Journal of Controlled Release, 2022 - Elsevier
Exosomes are nanovesicles with different contents that play a role in various biological and
pathological processes. It offers significant advantages over other delivery systems such as …