Control of stationary behavior in probabilistic Boolean networks by means of structural intervention

I Shmulevich, ER Dougherty… - Journal of Biological …, 2002 - World Scientific
Probabilistic Boolean Networks (PBNs) were recently introduced as models of gene
regulatory networks. The dynamical behavior of PBNs, which are probabilistic …

Intervention in context-sensitive probabilistic Boolean networks

R Pal, A Datta, ML Bittner, ER Dougherty - Bioinformatics, 2005 - academic.oup.com
Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable
states, such as those associated with a disease. Several types of intervention have been …

Gene perturbation and intervention in probabilistic Boolean networks

I Shmulevich, ER Dougherty, W Zhang - Bioinformatics, 2002 - academic.oup.com
Motivation: A major objective of gene regulatory network modeling, in addition to gaining a
deeper understanding of genetic regulation and control, is the development of …

External control in Markovian genetic regulatory networks

A Datta, A Choudhary, ML Bittner, ER Dougherty - Machine learning, 2003 - Springer
Abstract Probabilistic Boolean Networks (PBN's) have been recently introduced as a rule-
based paradigm for modeling gene regulatory networks. Such networks, which form a …

State reduction for network intervention in probabilistic Boolean networks

X Qian, N Ghaffari, I Ivanov, ER Dougherty - Bioinformatics, 2010 - academic.oup.com
Motivation: A key goal of studying biological systems is to design therapeutic intervention
strategies. Probabilistic Boolean networks (PBNs) constitute a mathematical model which …

Steady‐state analysis of genetic regulatory networks modelled by probabilistic Boolean networks

I Shmulevich, I Gluhovsky… - Comparative and …, 2003 - Wiley Online Library
Abstract Probabilistic Boolean networks (PBNs) have recently been introduced as a
promising class of models of genetic regulatory networks. The dynamic behaviour of PBNs …

[HTML][HTML] Recent development and biomedical applications of probabilistic Boolean networks

P Trairatphisan, A Mizera, J Pang, AA Tantar… - Cell communication and …, 2013 - Springer
Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used
for the study of the topology and dynamic aspects of biological systems. The combined use …

Stabilizing large-scale probabilistic Boolean networks by pinning control

L Lin, J Cao, J Lu, J Zhong, S Zhu - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
This article aims to stabilize probabilistic Boolean networks (PBNs) via a novel pinning
control strategy. In a PBN, the state evolution of each gene switches among a collection of …

Robust intervention in probabilistic Boolean networks

R Pal, A Datta, ER Dougherty - IEEE Transactions on Signal …, 2008 - ieeexplore.ieee.org
Probabilistic Boolean networks (PBNs) have been recently introduced as a paradigm for
modeling genetic regulatory networks. One of the objectives of PBN modeling is to use the …

External control in Markovian genetic regulatory networks: the imperfect information case

A Datta, A Choudhary, ML Bittner… - Bioinformatics, 2004 - academic.oup.com
Abstract Probabilistic Boolean Networks, which form a subclass of Markovian Genetic
Regulatory Networks, have been recently introduced as a rule-based paradigm for modeling …