Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been …
Motivation: A major objective of gene regulatory network modeling, in addition to gaining a deeper understanding of genetic regulation and control, is the development of …
Abstract Probabilistic Boolean Networks (PBN's) have been recently introduced as a rule- based paradigm for modeling gene regulatory networks. Such networks, which form a …
Motivation: A key goal of studying biological systems is to design therapeutic intervention strategies. Probabilistic Boolean networks (PBNs) constitute a mathematical model which …
I Shmulevich, I Gluhovsky… - Comparative and …, 2003 - Wiley Online Library
Abstract Probabilistic Boolean networks (PBNs) have recently been introduced as a promising class of models of genetic regulatory networks. The dynamic behaviour of PBNs …
Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use …
L Lin, J Cao, J Lu, J Zhong, S Zhu - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
This article aims to stabilize probabilistic Boolean networks (PBNs) via a novel pinning control strategy. In a PBN, the state evolution of each gene switches among a collection of …
Probabilistic Boolean networks (PBNs) have been recently introduced as a paradigm for modeling genetic regulatory networks. One of the objectives of PBN modeling is to use the …
A Datta, A Choudhary, ML Bittner… - Bioinformatics, 2004 - academic.oup.com
Abstract Probabilistic Boolean Networks, which form a subclass of Markovian Genetic Regulatory Networks, have been recently introduced as a rule-based paradigm for modeling …