The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear

V Laurent, AR Marchand, RF Westbrook - Learning & memory, 2008 - learnmem.cshlp.org
Extinction of conditioned fear involves new learning that inhibits but does not eliminate the
original fear memory. This inhibitory learning is thought to require activation of NMDA …

Infusion of the NMDA receptor antagonist, DL-APV, into the basolateral amygdala disrupts learning to fear a novel and a familiar context as well as relearning to fear …

V Laurent, RF Westbrook - Learning & Memory, 2009 - learnmem.cshlp.org
Ample evidence suggests that activation of NMDA receptors (NMDAr) in the basolateral
complex of the amygdala (BLA) is necessary for context fear conditioning. The present …

Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear

V Laurent, RF Westbrook - Learning & Memory, 2008 - learnmem.cshlp.org
We studied the roles of the basolateral amygdala (BLA) and the medial prefrontal cortex
(mPFC) in learning and relearning to inhibit context conditioned fear (freezing) in extinction …

Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution

F Sotres-Bayon, L Diaz-Mataix, DEA Bush… - Cerebral …, 2009 - academic.oup.com
Fear extinction, which involves learning to suppress the expression of previously learned
fear, requires N-methyl-D-aspartate receptors (NMDARs) and is mediated by the amygdala …

Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala

F Sotres-Bayon, DEA Bush, JE LeDoux - Neuropsychopharmacology, 2007 - nature.com
N-methyl-D-aspartate receptors (NMDARs) contribute to synaptic plasticity underlying
learning in a variety of brain systems. Fear extinction, which involves learning to suppress …

NMDA receptor antagonism in the basolateral but not central amygdala blocks the extinction of Pavlovian fear conditioning in rats

JM Zimmerman, S Maren - European Journal of Neuroscience, 2010 - Wiley Online Library
Glutamate receptors in the basolateral complex of the amygdala (BLA) are essential for the
acquisition, expression and extinction of Pavlovian fear conditioning in rats. Recent work …

Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats

H Lee, JJ Kim - Journal of Neuroscience, 1998 - Soc Neuroscience
NMDA receptors in the amygdala seem to be critical for fear conditioning in naive rats.
Recent spatial-learning studies suggest that previous learning protected animals from the …

The basolateral amygdala is critical for the acquisition and extinction of associations between a neutral stimulus and a learned danger signal but not between two …

SL Parkes, RF Westbrook - Journal of Neuroscience, 2010 - Soc Neuroscience
We studied the neural substrates of higher-order conditioned fear in rats. We first studied
acquisition and extinction of second-order fear. One stimulus (S1) was paired with a …

Amygdala-dependent and amygdala-independent pathways for contextual fear conditioning

R Ponnusamy, AM Poulos, MS Fanselow - Neuroscience, 2007 - Elsevier
The basolateral amygdala (BLA), consisting of the lateral and basal nuclei, is considered to
be essential for fear learning. Using a temporary inactivation technique, we found that rats …

Enhancement of extinction memory consolidation: the role of the noradrenergic and GABAergic systems within the basolateral amygdala

DJ Berlau, JL McGaugh - Neurobiology of learning and memory, 2006 - Elsevier
Evidence from previous studies indicates that the noradrenergic and GABAergic influences
within the basolateral amygdala (BLA) modulate the consolidation of memory for fear …