Introduction The blood-brain barrier (BBB) is damaged in tauopathies, including progressive
supranuclear palsy (PSP) and Alzheimer's disease (AD), which is thought to contribute to …

Vascular mechanisms of Alzheimer's disease (AD) may constitute a therapeutically
addressable biological pathway underlying dementia. We previously demonstrated that …

Mixed pathology, with both Alzheimer's disease and vascular abnormalities, is the most
common cause of clinical dementia in the elderly. While usually thought to be concurrent …

Tauopathies represent a heterogeneous group of neurodegenerative disorders
characterized by abnormal deposition of the hyperphosphorylated microtubule-associated …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most prevalent
cause of dementia. The main cerebral histological hallmarks are represented by …

The blood–brain barrier (BBB) plays a crucial role in maintaining the specialized
microenvironment of the central nervous system (CNS). In aging, the stability of the BBB …

Objective Elevated vascular risk and beta‐amyloid (Aβ) burden have been synergistically
associated with cognitive decline in preclinical Alzheimer's disease (AD), although the …

Alzheimer's Disease (AD) is associated with neuropathological changes, including
aggregation of tau neurofibrillary tangles (NFTs) and amyloid-beta plaques. Mounting …

The importance of vascular contributions to cognitive impairment and dementia (VCID)
associated with Alzheimer's disease (AD) and related neurodegenerative diseases is …

Small vessel cerebrovascular disease, visualized as white matter hyperintensities on T2-
weighted magnetic resonance imaging, contributes to the clinical presentation of …