DHEA enhances emotion regulation neurocircuits and modulates memory for emotional stimuli

RK Sripada, CE Marx, AP King, N Rajaram… - …, 2013 - nature.com
Dehydroepiandrosterone (DHEA) is a neurosteroid with anxiolytic, antidepressant, and
antiglucocorticoid properties. It is endogenously released in response to stress, and may …

[HTML][HTML] Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans

OT Wolf, C Kirschbaum - Brain Research Reviews, 1999 - Elsevier
Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, exert multiple effects in the
rodent central nervous system (CNS). Most of them seem to be mediated through their non …

The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting‐state amygdala connectivity

RK Sripada, RC Welsh, CE Marx… - Human brain …, 2014 - Wiley Online Library
The neurosteroids allopregnanolone and dehydroepiandrosterone (DHEA) are integral
components of the stress response and exert positive modulatory effects on emotion in both …

Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression

CM Hough, D Lindqvist, ES Epel, MS Denis… - …, 2017 - Elsevier
Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-
S),(together DHEA [S]), are the most abundant adrenal steroids in humans and are found in …

The protective effect of frontal cortex dehydroepiandrosterone in anxiety and depressive models in mice

R Maayan, D Touati-Werner, E Ram, R Strous… - Pharmacology …, 2006 - Elsevier
We aimed to verify whether DHEA, a neuoroactive neurosteroid, has a protective role in
preventing the occurrence or enhancement of the severity of depression and anxiety in mice …

Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study

HA Alhaj, AE Massey, RH McAllister-Williams - Psychopharmacology, 2006 - Springer
Rationale Dehydroepiandrosterone (DHEA) has been reported to enhance cognition in
rodents, although there are inconsistent findings in humans. Objectives The aim of this study …

Dehydroepiandrosterone (DHEA) treatment of depression

OM Wolkowitz, VI Reus, E Roberts, F Manfredi… - Biological …, 1997 - Elsevier
Dehydroepiandrosterone (DHEA) and its sulfate, DHEA-S, are plentiful adrenal steroid
hormones that decrease with aging and may have significant neuropsychiatric effects. In this …

DHEA lessens depressive-like behavior via GABA-ergic modulation of the mesolimbic system

R Genud, A Merenlender, I Gispan-Herman… - …, 2009 - nature.com
Alterations in the levels of dehydroepiandrosterone (DHEA) in the brain can allosterically
modulate γ-aminobutyric-acid-type-A (GABA AR), N-methyl-D-aspartate (NMDAR), and …

A single administration of dehydroepiandrosterone does not enhance memory performance in young healthy adults, but immediately reduces cortisol levels

OT Wolf, B Köster, C Kirschbaum, R Pietrowsky… - Biological …, 1997 - Elsevier
A Single Administration of Dehydroepiandrosterone Does Not Enhance Memory
Performance in Young Healthy Adults, but Immediately Reduces Cortisol Levels …

DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action

RB Dor, CE Marx, LJ Shampine, DR Rubinow… - …, 2015 - Springer
Background Alterations in neurosteroid secretion have been implicated in the efficacy of
antidepressants. In a previous study, the adrenal androgen DHEA, a precursor of the …