Cancer cells show a metabolic shift that makes them overproduce protons; this has the
potential to disturb the cellular acidbase homeostasis. However, these cells show …

The vacuolar ATPases are ATP-dependent proton pumps whose functions include the
acidification of intracellular compartments and the extrusion of protons through the cell …

Tumor cells in vivo often exist in a hypoxic microenvironment with a lower extracellular pH
than that surrounding normal cells. Ability to upregulate proton extrusion may be important …

Acidity is one of the main features of the tumors. The V-ATPase is the primary responsible for
the control of tumor microenvironment by proton extrusion to the extracellular medium. The …

Acidity is one of the main characteristics of OSCC (oral squamous cell carcinoma) as a solid
tumor. The V-ATPase is the primary regulator of the tumor microenvironment, by means of …

Tumor microenvironment may play a key role in tumor malignancy. It is hypothesized that
hypoxia and acidity may contribute to the progression from benign to malignant growth. In …

The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis
to proton transport into intracellular compartments and across the plasma membrane. They …

Resistance to cytotoxic agents is a major problem in treating cancer. The mechanisms
underlying this phenomenon appear to take advantage of functions involved in the control of …

Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …

Vacuolar-type ATPases are multicomponent proton pumps involved in the acidification of
single membrane intracellular compartments such as endosomes and lysosomes. They …