Microbes can be engineered to act like living therapeutics designed to perform specific
actions in the human body. From fighting and preventing infections to eliminating tumors and …

Recent advances in synthetic biology and biological system engineering have allowed the
design and construction of engineered live biotherapeutics targeting a range of human …

A complex interplay of metabolic and immunological mechanisms underlies many diseases
that represent a substantial unmet medical need. There is an increasing appreciation of the …

Advances in synthetic biology have enabled the engineering of cells with genetic circuits in
order to program cells with new biological behavior, dynamic gene expression, and logic …

Future advances in therapeutics demand the development of dynamic and intelligent living
materials. The past static monofunctional materials shall be unable to meet the requirements …

Synthetic biology aims to apply engineering principles to biology by modulating the behavior
of living organisms. An emerging application of this field is the engineering of bacteria as a …

Synthetic biology seeks to redesign biological systems to perform novel functions in a
predictable manner. Recent advances in bacterial and mammalian cell engineering include …

Bacteria are emerging as living drugs to treat a broad range of disease indications.
However, the inherent advantages of these replicating and immunostimulatory therapies …

In living organisms, naturally evolved sensors that constantly monitor and process
environmental cues trigger corrective actions that enable the organisms to cope with …

Highlights•Synthetic biology approaches enable microbial systems engineering.•Versatile
tools rapidly expand regulatory engineering capabilities.•Modular components and …