Cellular and molecular processes leading to abnormal accumulation of β amyloid in the
brain are slowly being uncovered. A potential involvement of insulin and insulin-like growth …

Most brain insulin comes from the pancreas and is taken up by the brain by what appears to
be a receptor‐based carrier. Type 2 diabetes animal models associated with insulin …

Recent data suggest that brains of patients with Alzheimer's disease (AD) are insulin and
insulin-like growth factor-1 (IGF-1) resistant. So far, there have been two different …

Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and
vascular dementia is growing exponentially. This review details what is currently known …

The possibility that perturbed insulin/insulin-like growth factor I (IGF-I) signalling is involved
in development of late-onset forms of Alzheimer's disease (AD) is gaining increasing …

The quality control of protein homoeostasis deteriorates with aging, causing the
accumulation of misfolded proteins and neurodegeneration. Thus, in AD (Alzheimer's …

Amyloid β (Aβ) peptides are direct competitive inhibitors of insulin binding and action [25].
We demonstrate that Aβ peptides can inhibit the effect of insulin on the metabolic processing …

Aging is characterized by a significant decline of metabolic and hormonal functions, which
often facilitates the onset of severe age-associated pathologies. One outstanding example of …

Although increased lifespan is associated with reduced insulin signaling, insulin signaling is
essential for neuronal development and survival. Insulin resistance is central to Type II …

The neurodegeneration that occurs in sporadic Alzheimer's disease (AD) is consistently
associated with a number of characteristic histopathological, molecular, and biochemical …