Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) is a
serine/threonine kinase essential for brain development and function, and its excessive …

DYRK1A is a pleiotropic protein kinase with diverse functions in cellular regulation,
including cell cycle control, neuronal differentiation, and synaptic transmission. Enhanced …

Down syndrome (DS) is associated with a variety of symptoms, such as incapacitating
mental retardation and neurodegeneration (ie, Alzheimer's disease), that prevent patients …

The protein kinase DYRK1A has been suggested to act as one of the intracellular regulators
contributing to neurological alterations found in individuals with Down syndrome. For an …

The Dyrk family of protein kinases is implicated in the pathogenesis of several diseases,
including cancer and neurodegeneration. Pharmacological inhibitors were mainly described …

The increasing population will challenge healthcare, particularly because the worldwide
population has never been older. Therapeutic solutions to age-related disease will be …

Dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) is a protein kinase
with diverse functions in neuronal development and adult brain physiology. Higher than …

The kinase DYRK1A is an attractive target for drug discovery programs due to its implication
in multiple diseases. Through a fragment screen, we identified a simple biaryl compound …

ABSTRACT DYRK1A is important in neuronal development and function, and its excessive
activity is considered a significant pathogenic factor in Down syndrome and Alzheimer's …

DYRK1A has been implicated as an important drug target in various therapeutic areas,
including neurological disorders and oncology. DYRK1A has more recently been shown to …