Present Alzheimer's disease (AD) therapies suffer from inefficient effects on AD symptoms
like memory or cognition, especially in later states of the disease. Used acteylcholine …

DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications
for embryonic development, especially in the nervous system where it regulates the balance …

Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

Harmine is a β-carboline alkaloid. The compound is a potent inhibitor of dual-specificity
tyrosine phosphorylation-regulated kinase 1A (Dyrk1A), a kinase implicated in Down …

The DYRK family contains kinases that are up-regulated in malignancy and control several
cancer hallmarks. To assess the anticancer potential of inhibitors targeting DYRK kinases …

Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …

According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …

DYRK kinases are involved in alternative pre-mRNA splicing as well as in neuropathological
states such as Alzheimer's disease and Down syndrome. In this study, we present the …

Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a
distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the …