Recent studies indicate that the dual‐specificity tyrosine phosphorylation‐regulated kinase
1A (DYRK1A) gene, which is located on chromosome 21q22. 2 and is overexpressed in …

Down syndrome (DS) caused by a trisomy of chromosome 21 (HSA21), is the most common
genetic developmental disorder, with an incidence of 1 in 800 live births. Its phenotypic …

DYRK1A (the dual specificity tyrosine phosphorylation-regulated kinase 1A) plays an
important role in body growth and brain physiology. Overexpression of this kinase has been …

Protein kinases (PKs) have been recognized as central nervous system (CNS)-disease-
relevant targets due to their master regulatory role in different signal transduction cascades …

Autoimmune deficiency and destruction in either β-cell mass or function can cause
insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β …

Summary Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key
roles in brain development, regulation of splicing, and apoptosis, and are potential drug …

DYRK1A is a dual‐specificity protein kinase that autophosphorylates a conserved tyrosine
residue in the activation loop but phosphorylates exogenous substrates only at serine or …

DYRK1A is a member of the dual‐specificity tyrosine‐phosphorylation‐regulated protein
kinase family and is implicated in Down's syndrome. Here, we identify the cysteine aspartyl …

Both tumour suppressive and oncogenic functions have been reported for dual-specificity
tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed …

Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases
(CLKs) recently attracted attention due to their central involvement in various pathologies …