The cellular response to a variety of stress including DNA damage is involved in cell cycle
arrest, activation of DNA repair, and in the event of irreparable damage, induction of …

Autophosphorylation of amino-acid residues is part of the folding process of various protein
kinases. Conventional chemical screening of mature kinases has missed inhibitors that …

Down syndrome is the main cause of intellectual disabilities with a large set of comorbidities
from developmental origins but also that appeared across life span. Investigation of the …

Dual specificity tyrosine phosphorylation-regulated kinases, DYRKs, are a family of
conserved protein kinases that play key roles in the regulation of cell differentiation …

Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced
in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the …

Despite advances in clinical management, 5-year survival rate in patients with late-stage
head and neck squamous cell carcinoma (HNSCC) has not improved significantly over the …

Down syndrome (DS) is the most common genetic disorder, characterized by mental
retardation, congenital heart abnormalities, and susceptibility to Alzheimer's disease (AD) …

But what is the point of dual specificity? Like other functionally related kinases, kinases of
the DYRK family need to be activated before they can phosphorylate their substrates. To …

Dyrk1A is a member of the mammalian Dyrk [dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase] family of protein kinases that is expressed at high levels in the brain, but its …