NF-κB signaling pathway and its therapeutic implications in human diseases

FH Sarkar, Y Li, Z Wang, D Kong - International reviews of …, 2008 - Taylor & Francis
The nuclear factor-κB (NF-κB) pathway is one of the most important cellular signal
transduction pathways involved in both physiologic processes and disease conditions. It …

Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches

MH Park, JT Hong - Cells, 2016 - mdpi.com
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

NF-κB signaling and carcinogenesis

T Okamoto, T Sanda, K Asamitsu - Current pharmaceutical …, 2007 - ingentaconnect.com
NF-κB is an inducible transcription factor that is controlled by the signal activation cascades.
NF-κB controls a number of genes involved in immuno-inflammatory responses, cell cycle …

NF‐κB as a potential molecular target for cancer therapy

CH Lee, YT Jeon, SH Kim, YS Song - Biofactors, 2007 - Wiley Online Library
Nuclear factor κB (NF‐κB), a transcription factor, plays an important role in carcinogenesis
as well as in the regulation of immune and inflammatory responses. NF‐κB induces the …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Role of the NFκB-signaling pathway in cancer

L Xia, S Tan, Y Zhou, J Lin, H Wang… - OncoTargets and …, 2018 - Taylor & Francis
Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present,
treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy …

NF-κB in biology and targeted therapy: new insights and translational implications

Q Guo, Y Jin, X Chen, X Ye, X Shen, M Lin… - … and Targeted Therapy, 2024 - nature.com
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

Y Lin, L Bai, W Chen, S Xu - Expert opinion on therapeutic targets, 2010 - Taylor & Francis
Importance of the field: Nuclear factor kappa B (NF-κB) is activated by a variety of cancer-
promoting agents. The reciprocal activation between NF-κB and inflammatory cytokines …

Transcriptional regulation during aberrant activation of NF-κB signalling in cancer

K Deka, Y Li - Cells, 2023 - mdpi.com
The NF-κB signalling pathway is a major signalling cascade involved in the regulation of
inflammation and innate immunity. It is also increasingly recognised as a crucial player in …