P Pan, M Shen, Z Yu, W Ge, K Chen, M Tian… - Nature …, 2021 - nature.com
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …
M Yalcinkaya, W Liu, MN Islam, AG Kotini… - Scientific reports, 2021 - nature.com
Despite the initial success of some drugs and vaccines targeting COVID-19, understanding the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the …
A Paniri, H Akhavan-Niaki - Life sciences, 2020 - Elsevier
The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global death toll is still rising. Exaggerated inflammatory responses are thought to be more …
J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a great threat to global public health since 2020. Although the advance on vaccine …
NE Kim, DK Kim, YJ Song - Microorganisms, 2021 - mdpi.com
Viral infection-induced activation of inflammasome complexes has both positive and negative effects on the host. Proper activation of inflammasome complexes induces down …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …
TS Rodrigues, DS Zamboni - Current Opinion in Immunology, 2023 - Elsevier
Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3 inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …
NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting innate immune responses. The deleterious effects of inflammasome activation have been …